Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quinine
Drug ID BADD_D01895
Description An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Indications and Usage For the treatment of malaria and leg cramps
Marketing Status Prescription
ATC Code P01BC01
DrugBank ID DB00468
KEGG ID D08460
MeSH ID D011803
PubChem ID 3034034
TTD Drug ID D03DDR
NDC Product Code 65162-811
Synonyms Quinine | Quinimax | Quinine Bisulfate | Bisulfate, Quinine | Quinine Hydrochloride | Hydrochloride, Quinine | Myoquin | Quinamm | Quinbisan | Legatrim | Quinine Lafran | Quinine Sulfate | Sulfate, Quinine | Quinine Sulphate | Sulphate, Quinine | Quinine-Odan | Quinoctal | Surquina | Biquinate | Strema | Quindan | Quinbisul | Quinson | Quinsul
Chemical Information
Molecular Formula C20H24N2O2
CAS Registry Number 72402-53-0
SMILES COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anuria20.01.03.002--Not Available
Aphasia19.21.01.001; 17.02.03.001--
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.002--Not Available
Azotaemia20.01.01.001--Not Available
Blindness17.17.01.003; 06.02.02.0010.006727%Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block right02.03.01.0110.003364%Not Available
Cardiac arrest02.03.04.001--
Cardiovascular disorder24.03.02.009; 02.01.01.0010.004387%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.004387%
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Chills15.05.03.016; 08.01.09.001--
Cinchonism12.03.01.034--Not Available
Coagulopathy01.01.02.001--Not Available
Colour blindness06.02.09.001; 03.01.01.001--Not Available
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