Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quetiapine
Drug ID BADD_D01888
Description Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [Clozapine] and [Olanzapine].[A2189]
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AH04
DrugBank ID DB01224
KEGG ID D08456
MeSH ID D000069348
PubChem ID 5002
TTD Drug ID D0H7KF
NDC Product Code 0615-7987; 50090-2307; 65862-877; 63629-4939; 16714-456; 65862-876; 0310-0275; 71610-538; 0093-8166; 70518-0239; 0093-8164; 71093-139; 65862-874; 33342-136; 63629-2482; 71205-402; 63629-2480; 50228-383; 16729-146; 71335-0432; 63629-2481; 68001-181; 63629-7116; 68001-183; 50090-2831; 50090-2338; 71205-026; 0615-7988; 80425-0107; 0615-8118; 70518-0570; 71205-401; 70518-0752; 16714-457; 50090-2689; 68001-180; 70518-0229; 16729-147; 50090-3749; 16729-148; 0310-0274; 50228-381; 70518-0432; 68788-7412; 50090-5451; 50090-2830; 16729-150; 65862-873; 71093-135; 71093-137; 53002-1529; 68001-182; 0310-0282; 0615-7986; 16714-454; 71093-138; 71093-136; 80425-0143; 68788-7185; 70518-0289; 68788-7186; 0310-0279; 16714-455; 16714-452; 50228-382; 33342-135; 68001-185; 50228-380; 60687-371; 16729-149; 68788-7590; 53002-1516; 65862-875; 33342-134; 0310-0278; 0310-0281; 63629-2478; 60687-338; 50090-4788; 68788-7184; 0093-8162; 0310-0284; 68001-184; 16729-145; 63629-2479; 0615-8119; 16714-453; 33342-137; 70518-2828; 0093-8163; 0310-0283; 68071-4161; 60687-327; 0093-8165; 60687-360; 50228-384; 60687-349; 0093-2063; 60687-382; 0310-0271; 0310-0272; 0310-0280
Synonyms Quetiapine Fumarate | Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt) | Seroquel | ICI 204,636 | ICI-204636 | ICI204636 | ICI 204636 | Quetiapine | 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
Chemical Information
Molecular Formula C21H25N3O2S
CAS Registry Number 111974-69-7
SMILES C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bradykinesia17.01.02.0040.003439%Not Available
Bradypnoea22.02.01.0020.001528%Not Available
Brain hypoxia24.04.06.022; 22.02.02.010; 17.08.02.0090.000266%Not Available
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Breast cyst21.05.01.006; 16.14.01.0040.000382%Not Available
Breast discharge21.05.05.0010.000382%Not Available
Breast engorgement21.05.05.002; 18.08.02.0010.000133%Not Available
Breast enlargement21.05.04.0010.000382%Not Available
Breast mass21.05.04.0020.000509%Not Available
Breast pain21.05.05.003--
Breast swelling21.05.05.008--Not Available
Breast tenderness21.05.05.0040.000382%Not Available
Breech presentation18.03.04.0010.000255%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.0120.000764%
Bruxism07.01.06.008; 19.11.03.0010.000382%Not Available
Buccoglossal syndrome17.01.02.013; 07.14.02.010--Not Available
Bundle branch block02.03.01.0090.000255%Not Available
Bundle branch block left02.03.01.0070.000509%Not Available
Bundle branch block right02.03.01.0110.001274%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
C-reactive protein increased13.09.01.007--Not Available
Cardiac arrest02.03.04.0010.002558%
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiac murmur13.14.01.0010.000199%Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.002060%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.002165%Not Available
Cardiomegaly02.04.02.0010.000199%Not Available
Cardiomyopathy02.04.01.0010.001783%Not Available
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