Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quetiapine
Drug ID BADD_D01888
Description Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [Clozapine] and [Olanzapine].[A2189]
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AH04
DrugBank ID DB01224
KEGG ID D08456
MeSH ID D000069348
PubChem ID 5002
TTD Drug ID D0H7KF
NDC Product Code 0615-7987; 50090-2307; 65862-877; 63629-4939; 16714-456; 65862-876; 0310-0275; 71610-538; 0093-8166; 70518-0239; 0093-8164; 71093-139; 65862-874; 33342-136; 63629-2482; 71205-402; 63629-2480; 50228-383; 16729-146; 71335-0432; 63629-2481; 68001-181; 63629-7116; 68001-183; 50090-2831; 50090-2338; 71205-026; 0615-7988; 80425-0107; 0615-8118; 70518-0570; 71205-401; 70518-0752; 16714-457; 50090-2689; 68001-180; 70518-0229; 16729-147; 50090-3749; 16729-148; 0310-0274; 50228-381; 70518-0432; 68788-7412; 50090-5451; 50090-2830; 16729-150; 65862-873; 71093-135; 71093-137; 53002-1529; 68001-182; 0310-0282; 0615-7986; 16714-454; 71093-138; 71093-136; 80425-0143; 68788-7185; 70518-0289; 68788-7186; 0310-0279; 16714-455; 16714-452; 50228-382; 33342-135; 68001-185; 50228-380; 60687-371; 16729-149; 68788-7590; 53002-1516; 65862-875; 33342-134; 0310-0278; 0310-0281; 63629-2478; 60687-338; 50090-4788; 68788-7184; 0093-8162; 0310-0284; 68001-184; 16729-145; 63629-2479; 0615-8119; 16714-453; 33342-137; 70518-2828; 0093-8163; 0310-0283; 68071-4161; 60687-327; 0093-8165; 60687-360; 50228-384; 60687-349; 0093-2063; 60687-382; 0310-0271; 0310-0272; 0310-0280
Synonyms Quetiapine Fumarate | Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt) | Seroquel | ICI 204,636 | ICI-204636 | ICI204636 | ICI 204636 | Quetiapine | 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
Chemical Information
Molecular Formula C21H25N3O2S
CAS Registry Number 111974-69-7
SMILES C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.01.0030.002675%
Alcohol intolerance14.02.01.001--
Alcoholism19.07.02.0010.000509%Not Available
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.015156%Not Available
Amblyopia06.02.01.001--Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Ammonia increased13.03.01.0230.000764%Not Available
Amnesia19.20.01.001; 17.03.02.0010.003566%
Amylase increased13.05.01.0090.000166%
Anaemia01.03.02.001--
Anaemia neonatal18.04.03.002; 01.03.02.0110.001019%Not Available
Anaesthetic complication pulmonary22.02.07.005; 12.02.12.0070.001274%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.0020.001783%Not Available
Anger19.04.02.0010.002547%Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Angle closure glaucoma06.03.01.0010.001656%Not Available
Anhedonia19.15.02.007--Not Available
Ankle fracture15.08.03.005; 12.04.01.0050.000509%
Anticholinergic syndrome17.05.01.0010.002547%Not Available
Anxiety19.06.02.0020.012227%
Apathy19.04.04.0020.002165%Not Available
Apgar score low13.15.01.0120.000382%Not Available
Aphasia17.02.03.001; 19.21.01.0010.001656%
Aplasia pure red cell10.02.01.003; 01.03.03.0010.000255%Not Available
Apnoea22.02.01.0010.000892%
Appendicitis11.01.07.001; 07.19.01.0010.000382%
Apraxia19.21.01.002; 17.02.03.0020.002547%Not Available
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