Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pyrazinamide
Drug ID BADD_D01880
Description A pyrazine that is used therapeutically as an antitubercular agent.
Indications and Usage For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.
Marketing Status approved; investigational
ATC Code J04AK01
DrugBank ID DB00339
KEGG ID D00144
MeSH ID D011718
PubChem ID 1046
TTD Drug ID D0XF8W
NDC Product Code 66639-165; 11712-815; 61748-012; 70954-484; 50090-0520; 70518-3661; 70518-2534; 50090-5963; 33342-447
UNII 2KNI5N06TI
Synonyms Pyrazinamide | Tisamid
Chemical Information
Molecular Formula C5H5N3O
CAS Registry Number 98-96-4
SMILES C1=CN=C(C=N1)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.002054%
Abdominal pain upper07.01.05.0030.001027%
Acne23.02.01.001--Not Available
Acute hepatic failure09.01.03.0010.002054%Not Available
Adrenocortical insufficiency acute14.11.01.020; 05.01.02.0050.001027%Not Available
Agranulocytosis01.02.03.0010.001027%Not Available
Altered state of consciousness19.07.01.003; 17.02.04.0010.002054%Not Available
Anaemia01.03.02.0010.002054%
Anuria20.01.03.0020.001540%Not Available
Arthralgia15.01.02.0010.003594%
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.001027%
Asthenia08.01.01.0010.006162%Not Available
Ataxia17.02.02.001; 08.01.02.0040.001027%
Blood iron increased13.11.01.007--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.12.02.0030.001027%Not Available
Cholestasis09.01.01.0010.001027%Not Available
Coagulopathy01.01.02.001--Not Available
Cough22.02.03.0010.001027%
Cutaneous vasculitis24.12.04.008; 10.02.02.003; 23.06.02.0010.001027%Not Available
Depressed level of consciousness17.02.04.0020.001027%
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.0010.003081%
Discomfort08.01.08.003--Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.002054%
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.0030.004108%
Dyspepsia07.01.02.001--
Dysuria20.02.02.002--
Eosinophilia01.02.04.0010.001027%
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