Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pyrazinamide
Drug ID BADD_D01880
Description A pyrazine that is used therapeutically as an antitubercular agent.
Indications and Usage For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.
Marketing Status Prescription
ATC Code J04AK01
DrugBank ID DB00339
KEGG ID D00144
MeSH ID D011718
PubChem ID 1046
TTD Drug ID D0XF8W
NDC Product Code 70518-2534; 66639-165; 70954-484; 61748-012; 33342-447; 50090-0520; 0904-6696; 11712-815; 49452-6135; 50090-0521; 71052-311
Synonyms Pyrazinamide | Tisamid
Chemical Information
Molecular Formula C5H5N3O
CAS Registry Number 98-96-4
SMILES C1=CN=C(C=N1)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.009182%
Acne23.02.01.001--Not Available
Acute hepatic failure09.01.03.0010.001796%Not Available
Adrenocortical insufficiency acute14.11.01.020; 05.01.02.0050.004591%Not Available
Agranulocytosis01.02.03.0010.004591%Not Available
Altered state of consciousness17.02.04.001; 19.07.01.0030.006887%Not Available
Anaemia01.03.02.0010.004591%
Anuria20.01.03.0020.006887%Not Available
Arthralgia15.01.02.0010.013773%
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.004591%
Aspartate aminotransferase increased13.03.01.0060.004591%
Asthenia08.01.01.0010.022955%Not Available
Blood creatine phosphokinase increased13.04.01.0010.006887%
Blood creatinine increased13.13.01.0040.009182%
Blood iron increased13.11.01.007--Not Available
Blood urea increased13.13.01.0060.004591%Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
C-reactive protein increased13.09.01.0070.004591%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.004591%Not Available
Cholestasis09.01.01.0010.001198%Not Available
Coagulopathy01.01.02.001--Not Available
Cough22.02.03.0010.004591%
Cutaneous vasculitis24.05.02.004; 23.06.02.001; 10.02.02.0030.004591%Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.0010.013773%
Discomfort08.01.08.003--Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.009182%
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.0070.018364%
Dyspepsia07.01.02.001--
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