Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pseudoephedrine hydrochloride
Drug ID BADD_D01877
Description Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889.[A188823] The decongestant effect of pseudoephedrine was described in dogs in 1927.[A188823]
Indications and Usage For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
Marketing Status OTC; Discontinued
ATC Code R01BA02
DrugBank ID DB00852
KEGG ID D00485
MeSH ID D054199
PubChem ID 9581
TTD Drug ID D00HHS
NDC Product Code 53943-204; 70518-2318; 50090-4546; 70518-2654; 65724-4415; 60646-102; 66653-004; 21130-204; 70677-0001; 49035-508; 50090-0155; 50090-3287; 30142-613; 24385-054; 58747-7538; 65724-4407; 62011-0306; 50580-250; 0113-0054; 51660-492; 10888-8168; 70518-3405; 65724-4400; 63552-075; 59779-204; 57218-801; 0904-5125; 37808-007; 0904-6727; 69842-189; 56062-204; 50580-240; 0904-6907; 0363-0204; 65724-4444; 70000-0475; 51927-0125; 50580-342; 65724-4401; 41163-054; 68016-204; 0113-0401; 51660-204; 50580-242; 50580-363; 36800-054; 59779-703; 30142-967; 65498-363; 30142-054; 50090-5554; 49452-6110; 50580-669; 46122-166; 50090-4629; 0904-6728; 54838-104; 50580-536; 63868-143; 70000-0164; 63187-541; 51927-1159; 41250-809; 68196-204
Synonyms Pseudoephedrine | Pseudoephedrine Hydrochloride | Pseudoephedrine HCl | Sudafed | Isoephedrine | Threo Isomer of Ephedrine | Ephedrine Threo Isomer
Chemical Information
Molecular Formula C10H16ClNO
CAS Registry Number 345-78-8
SMILES CC(C(C1=CC=CC=C1)O)NC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Insomnia19.02.01.002; 17.15.03.002--
Nervousness19.06.02.003--Not Available
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