Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
BradycardiaCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
HypotensionCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
HypotensionCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not Available3157382; 6324685; 2996181; 7994564; 6713449; 10370869; 2938592; 12498738; 2630100; 6316993
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 1A1P04798Not Available15094323; 11906967; 15224175
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oesophageal varices haemorrhage24.07.02.022; 09.01.06.004; 07.12.01.0030.000633%
Orthostatic hypotension24.06.03.004; 17.05.01.0200.000380%Not Available
Oxygen saturation decreased13.02.01.0040.000165%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pain of skin23.03.03.0030.000066%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.001393%Not Available
Palpitations02.01.02.0030.002152%
Pancreatitis07.18.01.001--
Panic attack19.06.04.0010.000253%Not Available
Panic reaction19.06.04.0030.000253%Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.0020.000760%
Paraesthesia17.02.06.005--
Paresis17.01.04.0080.000253%Not Available
Peripheral coldness08.01.09.010; 24.04.03.0060.004684%Not Available
Peyronie's disease21.12.01.002--Not Available
Phaeochromocytoma16.24.02.004; 05.01.04.0040.000253%Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.000633%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photophobia17.17.02.006; 06.01.01.0040.000253%
Pleural fibrosis22.05.03.0030.000253%Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonia klebsiella22.07.06.001; 11.02.03.0010.000066%Not Available
Polyarthritis15.01.01.0050.000253%Not Available
Polyhydramnios18.05.01.0020.000253%Not Available
Poor peripheral circulation24.04.03.0130.000380%Not Available
Premature baby18.04.02.001--Not Available
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.0070.000633%
Productive cough22.02.03.0050.000380%
Pruritus23.03.12.001--
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