Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
BradycardiaCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not Available3157382; 6324685; 2996181; 7994564; 6713449; 10370869; 2938592; 12498738; 2630100; 6316993
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 1A1P04798Not Available15094323; 11906967; 15224175
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Meningioma17.20.01.005; 16.30.01.0050.000253%Not Available
Mesenteric artery thrombosis24.01.08.003; 07.15.02.008--Not Available
Metabolic acidosis14.01.01.0030.000886%Not Available
Metrorrhagia21.01.01.0060.000253%Not Available
Middle insomnia19.02.01.003; 17.15.03.0030.001393%Not Available
Migraine24.03.05.003; 17.14.02.0010.001139%Not Available
Miosis17.02.11.002; 06.05.03.0030.000253%Not Available
Mood swings19.04.03.0010.000633%Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.0050.000380%Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Mydriasis17.02.11.003; 06.05.03.0040.001772%Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Myopathy15.05.05.001--Not Available
Myositis15.05.01.0010.000380%
Nasal congestion22.04.04.0010.001013%
Nasal septum ulceration22.04.03.0160.000253%Not Available
Nasopharyngitis11.01.13.002; 22.07.03.0020.002785%Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
Necrosis24.04.02.006; 08.03.03.0010.000380%Not Available
Nervous system disorder17.02.10.0010.000633%Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Nightmare19.02.03.0030.002785%Not Available
Ocular hyperaemia06.04.05.0040.000380%Not Available
Oculomucocutaneous syndrome23.03.01.022; 07.05.01.010; 06.04.05.014--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
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