Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
BradycardiaCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not Available3157382; 6324685; 2996181; 7994564; 6713449; 10370869; 2938592; 12498738; 2630100; 6316993
Poisoning and toxicityCytochrome P450 1A1P04798Not Available15094323; 11906967; 15224175
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchiolitis22.03.02.004; 11.05.04.0080.000886%Not Available
Bronchitis22.07.01.001; 11.01.09.0010.000633%
Bronchospasm10.01.03.012; 22.03.01.0040.001013%
Bundle branch block02.03.01.0090.000380%Not Available
Bundle branch block right02.03.01.0110.000506%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cardiac arrest02.03.04.0010.001816%
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.0050.000066%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000760%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.002785%Not Available
Cardiomegaly02.04.02.0010.000066%Not Available
Catatonia19.11.01.001--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000132%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.001393%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholestasis09.01.01.0010.000633%Not Available
Chromaturia20.02.01.0020.000380%
Circulatory collapse24.06.02.0010.001013%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000886%Not Available
Colitis ischaemic24.04.08.012; 07.08.01.004--Not Available
Coma17.02.09.0010.002152%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.001519%Not Available
Confusional state17.02.03.005; 19.13.01.0010.002785%
Constipation07.02.02.001--
Cough22.02.03.0010.004304%
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.0050.001139%Not Available
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