Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
BradycardiaCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
HypotensionCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not Available3157382; 6324685; 2996181; 7994564; 6713449; 10370869; 2938592; 12498738; 2630100; 6316993
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 1A1P04798Not Available15094323; 11906967; 15224175
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myocardial necrosis marker increased13.04.01.0130.000253%Not Available
Respiratory symptom22.02.08.0160.000253%Not Available
Sinus node dysfunction02.03.03.0170.000506%
Multiple organ dysfunction syndrome08.01.03.0570.000132%
Apnoeic attack22.02.01.027; 17.02.05.0510.000066%Not Available
Coeliac disease14.02.01.007; 10.04.04.012; 07.17.01.0080.000253%Not Available
Macroglossia03.04.09.003; 07.14.01.0110.000253%Not Available
Pupil fixed06.05.03.012; 17.02.11.0080.000380%Not Available
Wolff-Parkinson-White syndrome02.03.01.0160.000380%Not Available
Accelerated idioventricular rhythm02.03.04.0170.000506%Not Available
Infantile spitting up07.01.07.014; 18.04.11.0060.000633%Not Available
Asthmatic crisis22.03.01.0180.000253%Not Available
Fear of death19.06.03.0060.000253%Not Available
Gross motor delay19.22.01.004; 17.01.02.0210.001013%Not Available
Acute lung injury22.01.03.0100.000099%Not Available
Poor feeding infant18.04.06.006; 14.03.02.0220.000253%Not Available
Infantile haemangioma24.03.06.009; 16.02.01.0070.000506%Not Available
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