Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage Propranolol is indicated to treat hypertension.[L6907,L6904] Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.[L6904,L6907]
Marketing Status approved; investigational
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
UNII 9Y8NXQ24VQ
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cognitive disorder19.21.02.001; 17.03.03.0030.000294%
Purpura non-thrombocytopenic01.01.04.006--Not Available
Metabolic disorder14.11.01.0010.000053%Not Available
Pulseless electrical activity02.03.04.0200.000374%Not Available
Hypoperfusion24.06.02.0190.000160%Not Available
Restless legs syndrome17.02.07.008; 15.05.03.0120.000144%Not Available
Infrequent bowel movements07.02.02.0110.000363%Not Available
Angiopathy24.03.02.0070.000053%Not Available
Appetite disorder19.09.01.002; 14.03.01.0040.000363%Not Available
Cardiac disorder02.11.01.003--Not Available
Feeding disorder19.09.01.003; 14.03.02.0030.000235%Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Mental disorder19.07.01.002--Not Available
Metastatic neoplasm16.16.01.0070.000053%Not Available
Motor dysfunction15.05.06.006; 17.01.02.0310.000053%Not Available
Abnormal behaviour19.01.01.0010.000395%Not Available
Decreased appetite08.01.09.028; 14.03.01.0050.005443%
Erectile dysfunction21.03.01.007; 19.08.04.001--
Intervertebral disc disorder15.10.01.0030.000053%Not Available
Myotonia17.05.02.013; 15.05.04.013--Not Available
Ulcer haemorrhage08.03.06.003; 24.07.01.0400.000107%Not Available
Blood disorder01.05.01.004--Not Available
Disease recurrence08.01.03.0500.001474%Not Available
Drug intolerance08.06.01.0130.001352%Not Available
Psychotic disorder19.03.01.0020.000214%
Pulmonary toxicity22.01.02.007; 12.03.01.0130.000160%Not Available
Sinus disorder22.04.06.0020.000182%
Respiratory tract infection22.07.07.001; 11.01.08.017--Not Available
Poor quality sleep19.02.05.005; 17.15.04.0020.002142%Not Available
Arterial insufficiency24.04.02.005--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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