Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propofol
Drug ID BADD_D01864
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications and Usage Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Marketing Status Prescription; Discontinued
ATC Code N01AX10
DrugBank ID DB00818
KEGG ID D00549
MeSH ID D015742
PubChem ID 4943
TTD Drug ID D0A3HB
NDC Product Code 72572-612; 69135-0010; 52584-699; 0409-4699; 50090-4569; 0641-6194; 25021-608; 63323-269; 0069-0209; 0069-0234; 51504-0003; 58032-2019; 51662-1470; 14593-885; 51662-1471; 72572-583; 44657-0044; 70518-3256; 0591-2136; 72572-590; 0641-6195; 0641-6196; 72572-585; 72572-601; 51662-1293; 18124-027; 65219-427; 0069-0248; 65219-800; 23155-345; 72572-584; 0404-9943; 66064-1015; 52133-0023; 52584-098
Synonyms Propofol | 2,6-Diisopropylphenol | 2,6 Diisopropylphenol | 2,6-Bis(1-methylethyl)phenol | Disoprofol | Diprivan | Disoprivan | Fresofol | ICI-35,868 | ICI 35,868 | ICI35,868 | ICI-35868 | ICI 35868 | ICI35868 | Ivofol | Propofol Fresenius | Propofol MCT | Propofol Rovi | Propofol-Lipuro | Recofol | Aquafol | Propofol Abbott
Chemical Information
Molecular Formula C12H18O
CAS Registry Number 2078-54-8
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Clonus17.02.05.0020.001182%Not Available
Coagulopathy01.01.02.001--Not Available
Coma17.02.09.0010.004729%Not Available
Compartment syndrome24.04.05.006; 15.05.05.0050.001182%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.003598%Not Available
Confusional state19.13.01.001; 17.02.03.0050.003941%
Conversion disorder19.24.01.0010.000788%Not Available
Cough22.02.03.0010.017339%
Cyanosis02.01.02.002; 24.03.01.007; 22.02.02.0070.003941%
Death08.04.01.001--
Dehydration14.05.05.001--
Delayed recovery from anaesthesia17.02.04.011; 12.02.12.0030.002364%Not Available
Delirium19.13.02.0010.001970%
Delusion19.10.01.0010.000788%
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative10.01.01.004; 23.03.07.0010.001182%
Diaphragmatic paralysis22.09.02.002; 17.01.04.0140.000788%Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disinhibition19.05.01.002--Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.000411%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug abuse19.07.02.0100.004215%Not Available
Drug dependence19.07.02.0090.003153%Not Available
Drug effect increased08.06.01.011--Not Available
Drug eruption10.01.01.005; 08.01.06.015; 23.03.05.0010.000788%Not Available
Drug hypersensitivity10.01.01.0010.011822%Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.004--Not Available
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