Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propofol
Drug ID BADD_D01864
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications and Usage Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Marketing Status Prescription; Discontinued
ATC Code N01AX10
DrugBank ID DB00818
KEGG ID D00549
MeSH ID D015742
PubChem ID 4943
TTD Drug ID D0A3HB
NDC Product Code 72572-612; 69135-0010; 52584-699; 0409-4699; 50090-4569; 0641-6194; 25021-608; 63323-269; 0069-0209; 0069-0234; 51504-0003; 58032-2019; 51662-1470; 14593-885; 51662-1471; 72572-583; 44657-0044; 70518-3256; 0591-2136; 72572-590; 0641-6195; 0641-6196; 72572-585; 72572-601; 51662-1293; 18124-027; 65219-427; 0069-0248; 65219-800; 23155-345; 72572-584; 0404-9943; 66064-1015; 52133-0023; 52584-098
Synonyms Propofol | 2,6-Diisopropylphenol | 2,6 Diisopropylphenol | 2,6-Bis(1-methylethyl)phenol | Disoprofol | Diprivan | Disoprivan | Fresofol | ICI-35,868 | ICI 35,868 | ICI35,868 | ICI-35868 | ICI 35868 | ICI35868 | Ivofol | Propofol Fresenius | Propofol MCT | Propofol Rovi | Propofol-Lipuro | Recofol | Aquafol | Propofol Abbott
Chemical Information
Molecular Formula C12H18O
CAS Registry Number 2078-54-8
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Atrioventricular block complete02.03.01.0030.001970%
Blindness transient17.17.01.004; 06.02.02.0020.000788%Not Available
Blood creatine phosphokinase increased13.04.01.0010.002759%
Blood creatinine increased13.13.01.004--
Blood lactic acid increased13.02.01.0150.002759%Not Available
Blood osmolarity increased13.11.02.003--Not Available
Blood pressure abnormal13.14.03.0010.000788%Not Available
Blood pressure decreased13.14.03.0020.008670%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure systolic decreased13.14.03.0070.001576%Not Available
Blood triglycerides increased13.12.03.0010.000822%Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.014975%Not Available
Bronchospasm10.01.03.012; 22.03.01.0040.016157%
Bundle branch block02.03.01.009--Not Available
Burning sensation08.01.09.029; 17.02.06.0010.001182%Not Available
Cardiac arrest02.03.04.0010.006168%
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiac output decreased13.14.02.001--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.002364%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000925%Not Available
Cardiomyopathy02.04.01.0010.000788%Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cheilitis07.05.01.001; 23.03.03.0250.000788%
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.0010.008276%
Chromaturia20.02.01.0020.002364%
Circulatory collapse24.06.02.0010.006305%Not Available
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