Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propofol
Drug ID BADD_D01864
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications and Usage Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Marketing Status approved; investigational; vet_approved
ATC Code N01AX10
DrugBank ID DB00818
KEGG ID D00549
MeSH ID D015742
PubChem ID 4943
TTD Drug ID D0A3HB
NDC Product Code 52133-0023; 66064-1015; 14593-885; 63323-269; 0069-0209; 0069-0234; 23155-345; 25021-608; 65219-800; 70518-3256; 69135-0010; 0641-6195; 44657-0044; 16714-528; 51662-1293; 51662-1470; 72572-601; 0641-6196; 72572-590; 0641-6194; 0069-0248; 58032-2019; 0409-4699; 0409-6010; 0591-2136; 16714-977; 72572-612; 16714-690; 51662-1471; 51504-0003
UNII YI7VU623SF
Synonyms Propofol | 2,6-Diisopropylphenol | 2,6 Diisopropylphenol | 2,6-Bis(1-methylethyl)phenol | Disoprofol | Diprivan | Disoprivan | Fresofol | ICI-35,868 | ICI 35,868 | ICI35,868 | ICI-35868 | ICI 35868 | ICI35868 | Ivofol | Propofol Fresenius | Propofol MCT | Propofol Rovi | Propofol-Lipuro | Recofol | Aquafol | Propofol Abbott
Chemical Information
Molecular Formula C12H18O
CAS Registry Number 2078-54-8
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ventricular fibrillation02.03.04.0080.000625%
Ventricular tachycardia02.03.04.0100.001197%
Visual impairment06.02.10.013--Not Available
Vomiting07.01.07.003--
Wheezing22.03.01.0090.000625%
Mental status changes19.07.01.0010.000357%Not Available
Brain oedema17.07.02.003; 12.01.10.0100.000268%
Tachyarrhythmia02.03.02.0080.000357%Not Available
Left ventricular dysfunction02.04.02.0110.000179%
Bradyarrhythmia02.03.02.0150.000393%Not Available
Airway complication of anaesthesia12.02.20.001; 22.02.07.006--Not Available
Ventricular hypokinesia02.04.02.0130.000179%Not Available
Unwanted awareness during anaesthesia12.02.20.010--Not Available
Tonic clonic movements17.12.03.0060.001286%Not Available
Systemic inflammatory response syndrome10.02.01.008; 24.06.03.008; 08.01.05.0050.000179%Not Available
Injection site discolouration12.07.03.038; 08.02.03.038; 23.03.03.046--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Conjunctival hyperaemia06.04.01.004--Not Available
Haemodynamic instability24.03.02.0060.001340%Not Available
Musculoskeletal stiffness15.03.05.027--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.001--Not Available
Myoclonic epilepsy17.12.03.0070.000179%Not Available
Foetal death18.01.02.003; 08.04.01.0110.000179%
Haemorrhage24.07.01.002--Not Available
Metabolic disorder14.11.01.0010.000268%Not Available
Pulseless electrical activity02.03.04.0200.001679%Not Available
Nuchal rigidity17.05.02.006; 15.05.04.005--Not Available
Muscle relaxant therapy25.16.01.001--Not Available
Ventricular dysfunction02.04.02.005--Not Available
The 10th Page    First    Pre   10 11 12    Next   Last    Total 12 Pages