Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Proparacaine
Drug ID BADD_D01862
Description Proparacaine is a topical anesthetic drug of the amino ester group. It is found in ophthalmic solutions at a concentration of 0.5% as the hydrochloride salt.
Indications and Usage Used as a local (ophthalmic) anesthetic.
Marketing Status Prescription; Discontinued
ATC Code S01HA04
DrugBank ID DB00807
KEGG ID D08448
MeSH ID C005717
PubChem ID 4935
TTD Drug ID D0Q7ZG
NDC Product Code Not Available
Synonyms proxymetacaine | benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester | proparacaine | proxymethacaine | 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate | Alcaine | Chibro-Kerakain | Kainair | Kéracaine | proxymetacaine hydrochloride | proparacaine HCl | proxymetacaine monohydrochloride | benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, monohydrochloride*benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, monohydrochloride | proparacaine hydrochloride | 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride | Ocu-Caine | Ophthaine | Ophthetic | Parcaine | Proparakain-POS | AK-Taine | Minims Proxymetacaine Hydrochloride
Chemical Information
Molecular Formula C16H26N2O3
CAS Registry Number 499-67-2
SMILES CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Corneal disorder06.08.01.0040.000127%Not Available
Ulcerative keratitis10.02.01.021; 06.04.02.0040.004878%
Corneal leukoma06.06.03.0180.000445%Not Available
Persistent corneal epithelial defect12.01.04.028; 06.06.03.0190.002439%Not Available
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