Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propafenone hydrochloride
Drug ID BADD_D01857
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D00640
MeSH ID D011405
PubChem ID 36708
TTD Drug ID D0J2KV
NDC Product Code 0591-2286; 49884-210; 42291-545; 50090-1134; 63629-2105; 63629-2268; 42291-546; 68382-524; 53489-552; 63629-1988; 63629-2265; 60687-537; 70771-1525; 0591-2287; 50090-4227; 0591-0582; 50090-2975; 12598-6278; 12598-6220; 16714-827; 49706-0201; 68382-522; 68382-523; 16714-825; 66993-115; 0603-5450; 0591-0583; 68084-917; 59651-256; 65015-671; 64380-185; 64380-184; 0603-5448; 63629-2267; 62559-230; 0591-2285; 70771-1527; 70771-1526; 0603-5449; 62559-232; 42291-547; 51407-016; 68462-409; 53489-551; 63629-1989; 16571-736; 59651-258; 16571-738; 68108-0340; 0832-0741; 0173-0826; 0832-0740; 51407-017; 0832-0742; 60429-976; 12598-6218; 46016-0320; 16571-737; 63629-2271; 63629-2269; 63629-2272; 12780-4900; 60429-438; 64380-186; 63629-2273; 59651-257; 68462-410; 0173-0824; 49884-211; 65841-170; 66993-114; 53489-553; 62559-231; 60429-437; 12598-6283; 68462-408; 60687-185; 16714-826; 63629-2270; 0173-0823; 12598-6216; 63629-2266; 12598-6280; 49884-113
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H28ClNO3
CAS Registry Number 34183-22-7
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Supraventricular tachycardia02.03.03.012--
Systemic lupus erythematosus10.04.03.004; 23.03.02.006; 15.06.02.003--Not Available
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tremor17.01.06.002--
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Balance disorder17.02.02.007--Not Available
Contusion23.03.11.002; 15.03.01.008; 12.01.06.001; 24.07.06.001--
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.001--Not Available
Transaminases increased13.03.01.015--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Antinuclear antibody positive13.06.01.003--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Hot flush08.01.03.027; 24.03.01.005; 21.02.02.001--
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Psychotic disorder19.03.01.002--
Atrioventricular dissociation02.03.01.012--Not Available
Sinus node dysfunction02.03.03.017--
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