Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propafenone hydrochloride
Drug ID BADD_D01857
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D00640
MeSH ID D011405
PubChem ID 36708
TTD Drug ID D0J2KV
NDC Product Code 0591-2286; 49884-210; 42291-545; 50090-1134; 63629-2105; 63629-2268; 42291-546; 68382-524; 53489-552; 63629-1988; 63629-2265; 60687-537; 70771-1525; 0591-2287; 50090-4227; 0591-0582; 50090-2975; 12598-6278; 12598-6220; 16714-827; 49706-0201; 68382-522; 68382-523; 16714-825; 66993-115; 0603-5450; 0591-0583; 68084-917; 59651-256; 65015-671; 64380-185; 64380-184; 0603-5448; 63629-2267; 62559-230; 0591-2285; 70771-1527; 70771-1526; 0603-5449; 62559-232; 42291-547; 51407-016; 68462-409; 53489-551; 63629-1989; 16571-736; 59651-258; 16571-738; 68108-0340; 0832-0741; 0173-0826; 0832-0740; 51407-017; 0832-0742; 60429-976; 12598-6218; 46016-0320; 16571-737; 63629-2271; 63629-2269; 63629-2272; 12780-4900; 60429-438; 64380-186; 63629-2273; 59651-257; 68462-410; 0173-0824; 49884-211; 65841-170; 66993-114; 53489-553; 62559-231; 60429-437; 12598-6283; 68462-408; 60687-185; 16714-826; 63629-2270; 0173-0823; 12598-6216; 63629-2266; 12598-6280; 49884-113
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H28ClNO3
CAS Registry Number 34183-22-7
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial flutter02.03.03.003--
Atrioventricular block first degree02.03.01.004--
Atrioventricular block second degree02.03.01.005--
Bleeding time prolonged13.01.02.002--Not Available
Blood glucose increased13.02.02.002--Not Available
Bradycardia02.03.02.002--Not Available
Bundle branch block02.03.01.009--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002--Not Available
Cholestasis09.01.01.001--Not Available
Coma17.02.09.001--Not Available
Conduction disorder02.03.01.008--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
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