ADReCS

Pharmaceutical Information

Drug Name	Propafenone
Drug ID	BADD_D01856
Description	An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage	Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status	approved
ATC Code	C01BC03
DrugBank ID	DB01182
KEGG ID	D08435
MeSH ID	D011405
PubChem ID	4932
TTD Drug ID	D0J2KV
NDC Product Code	51407-478; 24979-086; 69680-130; 69680-131; 71205-942; 12598-6285; 71205-941; 24979-087; 24979-085; 51407-477; 71205-940; 69680-132; 51407-479
UNII	68IQX3T69U
Synonyms	Propafenone \| Propafenone Hydrochloride, (R)-Isomer \| Rytmo-Puren \| Rytmogenat \| SA-79 \| SA 79 \| SA79 \| Propafenone, (+-)-Isomer \| Propafenone, (R)-Isomer \| Propafenone, (S)-Isomer \| Propamerck \| Apo-Propafenone \| Baxarytmon \| Cuxafenon \| Fenoprain \| Jutanorm \| Nistaken \| Prolecofen \| Propafenon AL \| Propafenon Hexal \| Propafenone Hydrochloride \| Hydrochloride, Propafenone \| Propafenone Hydrochloride, (S)-Isomer \| Rythmol \| Propafenon Minden \| Norfenon \| Pintoform \| Rytmonorm \| Arythmol

Chemical Information

Molecular Formula	C21H27NO3
CAS Registry Number	54063-53-5
SMILES	CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Blood chloride decreased	13.11.01.004	-	-	Not Available
Blood cholesterol increased	13.12.01.002	-	-
Blood creatinine increased	13.13.01.004	-	-
Blood glucose increased	13.02.02.002	-	-	Not Available
Blood lactate dehydrogenase increased	13.04.02.002	-	-
Blood pressure decreased	13.14.03.002	-	-	Not Available
Blood pressure increased	13.14.03.005	-	-	Not Available
Blood prolactin increased	13.10.03.002	-	-	Not Available
Blood sodium decreased	13.11.01.012	-	-	Not Available
Blood triglycerides increased	13.12.03.001	-	-	Not Available
Blood urea increased	13.13.01.006	-	-	Not Available
Blood uric acid increased	13.02.04.001	-	-	Not Available
Body temperature increased	13.15.01.001	-	-	Not Available
Bone disorder	15.02.04.004	-	-	Not Available
Bradycardia	02.03.02.002	0.004180%		Not Available
Bradypnoea	22.02.01.002	0.000418%		Not Available
Breast pain	21.05.05.003	-	-
Breath odour	07.01.06.002	-	-	Not Available
Bundle branch block	02.03.01.009	-	-	Not Available
Bundle branch block left	02.03.01.007	-	-	Not Available
Bundle branch block right	02.03.01.011	0.000836%		Not Available
Bursitis	12.04.03.010; 15.04.01.001	-	-	Not Available
Cardiac arrest	02.03.04.001	0.012122%
Cardiac failure	02.05.01.001	0.001672%
Cardiac failure congestive	02.05.01.002	-	-	Not Available
Cardiac murmur	13.14.01.001	-	-	Not Available
Cardio-respiratory arrest	02.03.04.002; 22.02.06.007	-	-	Not Available
Cardiogenic shock	24.06.02.006; 02.05.01.003	0.001881%		Not Available
Cerebrovascular accident	17.08.01.007; 24.03.05.001	-	-
Chest pain	22.12.02.003; 08.01.08.002; 02.02.02.011	0.001463%		Not Available

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