Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propafenone
Drug ID BADD_D01856
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D08435
MeSH ID D011405
PubChem ID 4932
TTD Drug ID D0J2KV
NDC Product Code 51407-477; 51407-479; 24979-087; 71205-940; 12598-6285; 51407-478; 24979-085; 69680-130; 71205-941; 69680-132; 69680-131; 71205-942; 24979-086
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H27NO3
CAS Registry Number 54063-53-5
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.004790%
Abdominal pain upper07.01.05.0030.001916%
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Agitation19.06.02.001; 17.02.05.0120.002874%
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.0030.001916%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.001916%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.0010.002874%
Angina pectoris24.04.04.002; 02.02.02.0020.002874%
Angina unstable02.02.02.004; 24.04.04.004--Not Available
Anxiety19.06.02.0020.004790%
Apnoea22.02.01.001--
Arrhythmia02.03.02.0010.002999%Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.0060.001916%
Asthenia08.01.01.0010.005747%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.0020.014369%
Atrial flutter02.03.03.0030.001916%
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block first degree02.03.01.0040.004790%
Atrioventricular block second degree02.03.01.0050.001916%
Bleeding time prolonged13.01.02.002--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
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