Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Promethazine
Drug ID BADD_D01854
Description Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Indications and Usage For the treatment of allergic disorders, and nausea/vomiting.
Marketing Status Prescription; Discontinued
ATC Code D04AA10; R06AD02
DrugBank ID DB01069
KEGG ID D00494
MeSH ID D011398
PubChem ID 4927
TTD Drug ID D0T2XU
NDC Product Code 65162-678; 54348-117
Synonyms Promethazine | Prometazin | Proazamine | Rumergan | Diprazin | Isopromethazine | Phenergan | Phenargan | Phensedyl | Pipolfen | Pipolphen | Promet | Promethazine Hydrochloride | Hydrochloride, Promethazine | Prothazin | Pyrethia | Remsed | Atosil | Diphergan
Chemical Information
Molecular Formula C17H20N2S
CAS Registry Number 60-87-7
SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic enzyme increased13.03.01.0190.002785%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Drug intolerance08.06.01.0130.005569%Not Available
Psychotic disorder19.03.01.0020.005569%
Pulmonary function test decreased13.19.01.001--Not Available
Muscle contracture15.03.01.0100.004177%Not Available
Intellectual disability19.21.06.001; 17.03.07.0010.002785%Not Available
Posterior reversible encephalopathy syndrome17.13.02.0070.002785%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.004177%Not Available
Reversible cerebral vasoconstriction syndrome24.04.06.026; 18.06.01.004; 17.08.02.0140.002785%Not Available
Irregular breathing22.02.01.026--Not Available
Maternal drugs affecting foetus18.03.03.009; 12.03.03.0060.002785%Not Available
Neonatal respiratory distress syndrome22.11.02.010; 18.04.10.0030.002785%Not Available
Pyomyositis11.02.01.047; 15.05.01.0090.011138%Not Available
Consciousness fluctuating17.02.04.0190.004177%Not Available
Poor feeding infant18.04.06.006; 14.03.02.0220.011138%Not Available
Disorganised speech19.19.02.005; 17.02.08.0170.002785%Not Available
Helplessness19.01.02.0130.005569%Not Available
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