Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Promethazine
Drug ID BADD_D01854
Description Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946.[A189901] Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A190153,A190159,A190150,A190171] Promethazine was granted FDA approval before 29 March 1951.[A190177,L4000]
Indications and Usage For the treatment of allergic disorders, and nausea/vomiting.
Marketing Status Prescription; Discontinued
ATC Code D04AA10; R06AD02
DrugBank ID DB01069
KEGG ID D00494
MeSH ID D011398
PubChem ID 4927
TTD Drug ID D0T2XU
NDC Product Code 65162-678; 54348-117
Synonyms Promethazine | Prometazin | Proazamine | Rumergan | Diprazin | Isopromethazine | Phenergan | Phenargan | Phensedyl | Pipolfen | Pipolphen | Promet | Promethazine Hydrochloride | Hydrochloride, Promethazine | Prothazin | Pyrethia | Remsed | Atosil | Diphergan
Chemical Information
Molecular Formula C17H20N2S
CAS Registry Number 60-87-7
SMILES CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000726%Not Available
Catatonia19.11.01.001--Not Available
Cellulitis23.09.01.001; 11.02.01.0010.002785%Not Available
Cerebellar syndrome17.02.02.0020.004177%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.0010.008354%
Cholecystitis chronic09.03.01.0040.002785%Not Available
Coma17.02.09.001--Not Available
Compartment syndrome24.04.05.006; 15.05.05.0050.002785%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.003632%Not Available
Confusional state19.13.01.001; 17.02.03.0050.023669%
Constipation07.02.02.001--
Conversion disorder19.24.01.001--Not Available
Coordination abnormal17.02.02.004--Not Available
Cough22.02.03.001--
Crohn's disease10.02.01.005; 07.08.01.0150.004177%Not Available
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.0050.006962%Not Available
Death08.04.01.001--
Delirium19.13.02.0010.013923%
Depressed level of consciousness17.02.04.0020.019492%
Depressed mood19.15.02.0010.004177%Not Available
Depression19.15.01.0010.008354%
Derealisation19.10.02.0010.002785%Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disorientation19.13.01.002; 17.02.05.0150.008354%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.008354%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
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