Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Procarbazine hydrochloride
Drug ID BADD_D01847
Description An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Indications and Usage For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Marketing Status Prescription
ATC Code L01XB01
DrugBank ID DB01168
KEGG ID D00478
MeSH ID D011344
PubChem ID 9703
TTD Drug ID D08GYO
NDC Product Code 43744-453; 54482-054; 48087-0050; 48087-0085; 72969-063; 14096-128
Synonyms Procarbazine | Procarbazine Monohydrobromide | Monohydrobromide, Procarbazine | Procarbazine Hydrochloride | Hydrochloride, Procarbazine | Procarbazine Monohydrochloride | Monohydrochloride, Procarbazine | Matulane | Natulan
Chemical Information
Molecular Formula C12H19N3O.ClH
CAS Registry Number 366-70-1
SMILES CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paraesthesia17.02.06.005--
Peroneal nerve palsy17.09.02.003--Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Photophobia06.01.01.004; 17.17.02.006--
Pleural effusion22.05.02.002--
Pneumonitis22.01.01.006--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Seizure17.12.03.001--
Skin hyperpigmentation23.05.01.003--
Somnolence19.02.05.003; 17.02.04.006--
Stomatitis07.05.06.005--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tremor17.01.06.002--
Urticaria10.01.06.001; 23.04.02.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Balance disorder17.02.02.007--Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
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