Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Procaine
Drug ID BADD_D01844
Description A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in treatment-experienced HIV patients [L1215].
Indications and Usage Used as a local anesthetic primarily in oral surgery
Marketing Status Discontinued
ATC Code C05AD05; N01BA02; S01HA05
DrugBank ID DB00721
KEGG ID D08422
MeSH ID D011343
PubChem ID 4914
TTD Drug ID D0TZ1G
NDC Product Code 51927-5144
Synonyms Procaine | Gerokit | Novocain | Novocaine | Procain Braun | Procain curasan | Procain Rödler | Procain Jenapharm | Procain Steigerwald | procain-loges | Procaina Serra | Procaine Hydrochloride | Hydrochloride, Procaine | Pröcaine chlorhydrate Lavoisier | Röwo Procain | Anuject | Geriocaine | Hewedolor-Procain | Lophakomp-Procain N
Chemical Information
Molecular Formula C13H20N2O2
CAS Registry Number 59-46-1
SMILES CCN(CC)CCOC(=O)C1=CC=C(C=C1)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sneezing22.02.05.011--
Somnolence19.02.05.003; 17.02.04.006--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Ventricular arrhythmia02.03.04.006--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Vasodilation procedure25.03.01.001--Not Available
Post lumbar puncture syndrome12.02.04.004; 17.14.01.012--Not Available
Pseudocholinesterase deficiency14.14.06.001; 03.08.06.001--Not Available
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