Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Primidone
Drug ID BADD_D01840
Description Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures.[L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949.[A189522] Primidone was granted FDA Approval on 8 March 1954.[L11112]
Indications and Usage For the treatment of epilepsy
Marketing Status Prescription; Discontinued
ATC Code N03AA03
DrugBank ID DB00794
KEGG ID D00474
MeSH ID D011324
PubChem ID 4909
TTD Drug ID D0U5RT
NDC Product Code 68084-202; 71610-079; 59348-0001; 72789-178; 63629-7811; 71610-191; 72789-177; 66490-691; 0615-8206; 65162-545; 17205-308; 71610-540; 71610-590; 0527-1301; 65162-544; 17205-307; 68682-690; 71610-005; 50090-1622; 55111-477; 53746-544; 42291-509; 50268-687; 0527-1231; 69584-685; 0904-5559; 72189-216; 69575-4045; 55111-876; 69584-684; 50268-686; 55111-476; 42291-511; 68084-203; 53746-545; 71335-1158; 68682-691; 0591-5321; 51927-2339; 10135-522; 66490-690; 71335-1965; 50090-4083; 49452-6020; 10135-540
Synonyms Primidone | Liskantin | Mylepsinum | Resimatil | Desoxyphenobarbital | Mizodin | Mysoline | Apo-Primidone | Apo Primidone | Primaclone | Sertan | Misodine | Primidon Holsten
Chemical Information
Molecular Formula C12H14N2O2
CAS Registry Number 125-33-7
SMILES CCC1(C(=O)NCNC1=O)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Hepatic cirrhosisAlanine aminotransferase 1P24298Not Available3997653; 7118708; 6698876
Hepatic cirrhosisAlanine aminotransferase 1P24298Not Available6648747; 6518350; 3510392; 7049029
JaundiceGlutathione hydrolase 7Q9UJ14T251226648747; 6518350; 3510392; 7049029
JaundiceAlkaline phosphatase, tissue-nonspecific isozymeP05186T095386648747; 6518350; 3510392; 7049029
JaundiceAlanine aminotransferase 1P24298Not Available3997653; 7118708; 6698876
JaundiceAlanine aminotransferase 1P24298Not Available6648747; 6518350; 3510392; 7049029
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary artery stenosis congenital24.04.09.012; 22.06.03.007; 03.07.09.0080.001546%Not Available
Rectal stenosis07.13.05.0030.001546%
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