Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pregabalin
Drug ID BADD_D01835
Description Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter.[A173995] It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions.[A187190] Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels.[A187190][L7066] Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).[L1006][L7066] It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.[A31161]
Indications and Usage Pregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, and postherpetic neuralgia. It is not approved for the management of fibromyalgia or as adjuntive therapy for adult partial onset seizures.[FDA label]
Marketing Status Prescription
ATC Code N03AX16
DrugBank ID DB00230
KEGG ID D02716
MeSH ID D000069583
PubChem ID 5486971
TTD Drug ID D00WUF
NDC Product Code 69238-1315; 72189-032; 71335-1476; 0228-2860; 59762-1354; 63539-014; 59762-1364; 72189-028; 55700-956; 59762-1348; 64980-413; 71335-1791; 71335-2012; 71335-1744; 76420-124; 55700-827; 0071-1017; 72189-269; 43598-297; 72658-0811; 71205-556; 53869-1473; 80425-0129; 69539-012; 80425-0124; 55700-804; 71335-1745; 72189-035; 72189-023; 76420-099; 69097-957; 69367-326; 60219-1317; 76282-574; 27808-237; 55700-805; 80425-0123; 68788-7524; 76282-572; 76420-097; 76420-100; 59762-1576; 0071-1012; 42419-019; 76420-121; 42385-308; 76420-123; 71205-298; 69097-955; 63629-3369; 64980-414; 71335-1790; 72658-0812; 69097-956; 71205-876; 69097-961; 66174-0031; 69367-329; 72189-251; 80425-0185; 60219-1316; 72189-033; 60219-1314; 66651-915; 0228-2858; 60219-1310; 31722-614; 43598-296; 69238-1317; 72658-0849; 72658-0808; 55154-2431; 76420-118; 31722-615; 72658-0813; 0071-1018; 27808-235; 69539-015; 69367-330; 71610-356; 47781-381; 72606-008; 60687-506; 51407-510; 0228-2861; 0904-7004; 71335-1300; 43353-263; 47335-691; 63304-048; 71335-1822; 69097-954; 0071-1026; 60760-205; 62350-0072; 76420-098; 53869-1016; 55154-2430; 70518-2763; 72189-021; 71335-1505; 60219-1312; 63629-8198; 71335-2015; 71610-316; 53869-1018; 0071-1019; 0904-7005; 71335-2000; 0071-1016; 72888-051; 70518-2571; 71610-351; 0904-7002; 62332-121; 71610-358; 45865-126; 69367-331; 55700-904; 50436-0325; 0904-7003; 71610-331; 63539-024; 68788-7523; 76282-569; 70518-2568; 31722-616; 71610-334; 55700-817; 15894-0016; 71205-875; 71335-1459; 72189-020; 60687-495; 60687-517; 76282-568; 72888-049; 66039-926; 80425-0025; 47335-688; 63629-8196; 69238-1312; 72205-013; 68788-7656; 71205-304; 46708-125; 72658-0814; 69539-128; 70518-2948; 71205-338; 60687-484; 71205-871; 64980-417; 80425-0029; 53869-1014; 71610-365; 80425-0147; 53869-1010; 43353-414; 71610-333; 71610-328; 71335-1792; 63629-4181; 70518-2745; 50228-350; 43598-291; 72643-010; 71335-1758; 60219-1315; 50370-0013; 65015-857; 72189-034; 80425-0026; 66577-034; 80425-0152; 67877-466; 47335-687; 50090-5071; 0228-2862; 67877-465; 76282-573; 55700-964; 63629-8199; 43598-295; 43353-264; 47781-379; 70518-2980; 31722-611; 63629-8208; 60760-486; 64980-412; 16812-003; 70518-2525; 69539-018; 59762-1360; 59285-002; 0071-1027; 0228-2859; 80425-0166; 69238-1314; 60219-1311; 76282-570; 71205-869; 72640-002; 69539-129; 27808-236; 47781-380; 67877-467; 72606-007; 80425-0028; 76420-117; 70518-2762; 53869-1013; 72189-164; 72658-0809; 60760-509; 65862-790; 47335-690; 61919-503; 63629-8197; 71205-323; 80425-0116; 72189-019; 0071-1020; 50090-5038; 50090-5177; 27808-239; 55700-891; 70518-3345; 62332-123; 60219-1313; 70518-2689; 69367-325; 70518-2569; 67877-463; 69238-1311; 71610-317; 69367-328; 50228-355; 51407-511; 68788-7521; 70518-2364; 17337-0421; 70518-2290; 0071-1014; 69539-011; 50228-357; 69097-962; 69097-959; 0071-1013; 71610-335; 43598-294; 55289-257; 71610-319; 43353-675; 76282-575; 46708-120; 71205-396; 55111-882; 0071-1015; 43598-293; 47335-693; 72189-328; 63629-8195; 72189-045; 62332-119; 60687-473; 69238-1310; 59762-1342; 71610-071; 67877-468; 53869-1011; 72205-018; 62332-124; 0228-2857; 71610-329; 45865-108; 71610-330; 71610-361; 71205-608; 72205-017; 50228-354; 71205-873; 67877-462; 71610-357; 31722-612; 43598-298; 72205-012; 63629-8248; 62332-125; 68724-1235; 50228-356; 55289-569; 69238-1316; 60760-507; 59762-1351; 69097-958; 0228-2863; 69238-1313; 50228-351
Synonyms Pregabalin | (S)-3-(aminomethyl)-5-methylhexanoic acid | 3-isobutyl GABA | 3 isobutyl GABA | GABA, 3-isobutyl | 3-(aminomethyl)-5-methylhexanoic acid | (R-)-3-isobutyl GABA | (S+)-3-isobutyl GABA | Lyrica | CI 1008 | 1008, CI | CI-1008 | CI1008
Chemical Information
Molecular Formula C8H17NO2
CAS Registry Number 148553-50-8
SMILES CC(C)CC(CC(=O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Negative thoughts19.15.02.0120.000354%Not Available
Sopor19.02.04.002; 17.02.04.021--Not Available
Spinal deformity15.10.04.0100.000354%Not Available
General physical condition abnormal13.15.01.040--Not Available
Cystic lymphangioma16.18.01.005; 03.15.05.002; 01.09.01.0220.000236%Not Available
Wound infection staphylococcal12.02.05.051; 11.02.05.0140.000472%Not Available
Diabetic foot24.04.03.015; 23.07.03.008; 17.09.04.006; 14.07.06.001; 05.07.06.0010.000236%Not Available
Communication disorder19.19.01.0080.000236%Not Available
Foot deformity15.10.03.0050.001180%Not Available
Hand deformity15.10.03.0070.000236%Not Available
Facial nerve disorder17.04.03.0060.000236%
Retinoschisis06.09.03.0250.000236%Not Available
Grip strength decreased13.15.01.0410.000236%Not Available
Foaming at mouth17.02.05.056; 08.01.03.070; 07.05.05.0190.000236%Not Available
Amphetamines positive13.17.02.0090.000236%Not Available
Pruritus allergic23.03.12.010; 10.01.03.0460.000236%Not Available
Spondylolisthesis15.10.04.0040.000354%Not Available
Faecal vomiting07.01.07.0130.000236%Not Available
Age-related macular degeneration06.09.03.0180.000708%Not Available
Gastric fistula12.02.03.018; 07.11.05.0110.000354%
Diastolic hypotension24.06.03.0120.000354%Not Available
Bone contusion24.07.06.019; 15.02.04.025; 12.01.08.0410.000236%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.012--Not Available
Basal ganglia haemorrhage17.08.01.039; 24.07.04.0210.000062%Not Available
Thrombotic cerebral infarction24.01.04.017; 17.08.01.0630.000236%Not Available
Oral mucosal erythema07.05.05.0230.000236%Not Available
Apparent death08.01.03.0620.000826%Not Available
Dysmetropsia17.17.01.022; 06.02.06.0170.000236%Not Available
Quality of life decreased13.18.01.013--Not Available
Cardiorenal syndrome20.01.03.018; 02.05.01.0120.000354%Not Available
The 54th Page    First    Pre   54 55    Next   Last    Total 55 Pages