ADReCS

Pharmaceutical Information

Drug Name	Prednisone
Drug ID	BADD_D01834
Description	A synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]
Indications and Usage	Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.[L10502]
Marketing Status	approved; vet_approved
ATC Code	A07EA03; H02AB07
DrugBank ID	DB00635
KEGG ID	D00473
MeSH ID	D011241
PubChem ID	5865
TTD Drug ID	D0IL7L
NDC Product Code	80425-0068; 82982-041; 0591-5052; 42291-727; 42708-105; 43063-911; 50090-0439; 50090-3361; 51655-242; 53002-0610; 55154-4950; 58118-0173; 59746-175; 60219-1707; 61919-321; 62135-471; 63187-066; 63629-2255; 63629-2263; 0378-0642; 64380-949; 67296-0138; 67296-1194; 67296-1755; 68071-2304; 68071-5242; 70518-0632; 70518-2115; 70518-2138; 71205-729; 71205-755; 71205-818; 0054-4741; 71335-1926; 0591-5443; 71335-2153; 0603-5336; 76420-068; 80425-0069; 82982-042; 10135-777; 10135-779; 50090-3137; 51655-493; 51655-763; 51655-765; 51655-779; 55154-4938; 59746-171; 60760-932; 63187-807; 63629-2254; 63629-2434; 64380-835; 66267-173; 66267-860; 67296-1444; 68071-2661; 68071-4691; 68071-5195; 68788-7372; 68788-7692; 68788-8166; 68788-9551; 70518-2675; 70518-2704; 70518-3540; 70934-880; 70954-060; 71205-741; 71335-2088; 0054-8739; 72162-1169; 72189-275; 0615-8438; 80425-0105; 64958-0002; 43063-968; 50090-6225; 51655-410; 51655-988; 53002-3090; 54348-506; 55154-4946; 55289-330; 55700-208; 60219-1705; 61919-235; 61919-365; 63629-7917; 67296-0140; 0054-0019; 68788-8212; 70954-061; 71205-089; 71335-1780; 71335-2149; 0054-8724; 0054-8740; 0054-9828; 72162-1170; 0615-8307; 0615-8441; 59651-489; 60760-002; 63629-2256; 64380-782; 67296-1183; 0054-0018; 70518-1553; 70518-2916; 70934-095; 70954-057; 71205-460; 71205-797; 71335-2122; 71335-2134; 0603-5337; 71610-721; 0054-9818; 0615-8306; 72189-489; 0615-8439; 80425-0106; 0904-6923; 13672-033; 10135-778; 43063-703; 45865-670; 53002-3252; 59746-172; 60687-145; 60760-255; 60760-790; 61919-108; 63187-085; 63629-2258; 63629-2435; 0378-0641; 68071-2209; 68071-2578; 68071-3143; 68788-6440; 68788-7752; 68788-8267; 70954-059; 71205-537; 71335-1524; 71335-1628; 71335-1736; 71335-1737; 71335-2051; 0603-5335; 0603-5339; 0615-8440; 75987-021; 75987-022; 0591-5442; 13672-032; 42708-115; 50090-3336; 51655-355; 51655-416; 51655-935; 51655-972; 59651-487; 60219-1708; 62135-470; 63187-300; 63187-997; 63629-2260; 63629-2262; 68071-1779; 68788-8116; 0527-2934; 70518-0305; 70518-0306; 70518-1120; 70882-117; 0054-4742; 71335-1516; 71335-1525; 0603-5338; 76420-067; 13672-031; 51552-0028; 10135-774; 42708-136; 50090-6123; 50090-6259; 51655-068; 51655-359; 51655-701; 53002-3091; 53002-3520; 59651-488; 60687-122; 63187-243; 63629-1579; 63629-2261; 0378-0640; 64380-784; 64380-785; 67296-0247; 67296-1065; 67296-1455; 67296-1457; 68071-2696; 68071-5196; 68071-5233; 0527-2933; 70518-1561; 70518-2676; 70518-3138; 71205-403; 71335-0464; 0615-8395; 72789-235; 0904-7127; 42708-167; 50090-3330; 50090-3354; 50090-5816; 51407-356; 51407-360; 51655-726; 55154-4949; 59651-484; 60760-715; 63629-2257; 68071-2781; 68788-8184; 0527-2930; 70518-0307; 70518-2555; 70518-3142; 70934-096; 70954-056; 71205-407; 71335-0623; 0054-4728; 0054-9817; 72162-1171; 75987-020; 10135-776; 60722-1002; 82298-103; 42291-771; 42708-114; 42708-166; 51655-349; 51655-760; 59651-486; 59746-173; 60219-1706; 60760-615; 63187-037; 67296-1083; 67296-1446; 67544-399; 0054-0017; 70518-3537; 70934-291; 0054-3722; 71205-362; 71335-0335; 71335-0508; 71335-2079; 71610-641; 72162-1172; 72189-246; 80425-0193; 38779-0154; 57582-003; 42708-045; 43063-866; 50090-6122; 51407-355; 51407-357; 51655-197; 51655-541; 51655-716; 53002-3250; 55700-203; 55700-209; 60687-134; 61919-326; 63187-020; 63629-1605; 63629-2259; 63629-2264; 63739-588; 64380-783; 67296-1203; 67296-1767; 67296-1886; 68071-2771; 70518-2314; 70518-2703; 70518-3401; 70518-3476; 70518-3539; 70518-3555; 70954-058; 71205-239; 71205-421; 71205-665; 71335-1915; 71335-2069; 71335-2160; 71335-9715; 72189-430; 0615-8391; 76420-069; 49452-6000; 10135-775; 42291-770; 42291-783; 50090-4785; 50090-5814; 50090-6376; 51407-358; 51407-359; 51655-208; 51655-939; 55154-3564; 58118-5442; 59651-485
UNII	VB0R961HZT
Synonyms	Prednisone \| Dehydrocortisone \| delta-Cortisone \| Rectodelt \| Prednison Hexal \| Sterapred \| Ultracorten \| Winpred \| Apo-Prednisone \| Cortan \| Cortancyl \| Panafcort \| Cutason \| Decortin \| Dacortin \| Decortisyl \| Deltasone \| Encortone \| Encorton \| Enkortolon \| Kortancyl \| Liquid Pred \| Meticorten \| Orasone \| Panasol \| Predni Tablinen \| Prednidib \| Predniment \| Prednison Acsis \| Acsis, Prednison \| Pronisone \| Sone \| Prednison Galen

Chemical Information

Molecular Formula	C21H26O5
CAS Registry Number	53-03-2
SMILES	CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Immune reconstitution inflammatory syndrome associated Kaposi's sarcoma	16.33.02.003; 11.05.17.012; 10.02.01.081; 08.06.02.025	0.000009%		Not Available
Immune thrombocytopenia	10.02.01.083; 01.08.01.013	0.000031%		Not Available
Immune-mediated enterocolitis	10.02.01.084; 07.08.01.021	-	-	Not Available
Immune-mediated myositis	15.05.01.012; 10.02.01.088	0.000054%		Not Available
Immunoglobulin G4 related disease	15.06.01.020; 10.04.04.028	0.000013%		Not Available
Inadequate analgesia	08.06.01.040; 12.02.20.006	0.000020%		Not Available
Infusion site bruising	12.07.05.022; 08.02.05.022; 24.07.06.030; 23.03.11.034	-	-	Not Available
Infusion site discomfort	12.07.05.027; 08.02.05.027	-	-	Not Available
Injection site hypoaesthesia	17.02.06.051; 12.07.03.060; 08.02.03.060	-	-	Not Available
Intra-abdominal fluid collection	21.07.04.014; 07.07.01.014	0.000009%		Not Available
Left ventricular dilatation	02.04.02.044	0.000013%		Not Available
Limb mass	15.03.05.019	-	-	Not Available
Loss of therapeutic response	08.06.01.041	0.000013%		Not Available
Lung hernia	22.02.07.023	0.000027%		Not Available
Lung opacity	22.12.01.006	0.000022%		Not Available
Lupus enteritis	15.06.02.015; 10.04.03.015; 07.08.03.023	0.000018%		Not Available
Malacoplakia	08.01.05.018; 11.07.01.023; 10.03.02.008	0.000009%		Not Available
Mast cell activation syndrome	10.02.01.090; 01.05.01.030	0.000013%		Not Available
Mechanic's hand	23.01.01.010; 15.06.01.021	0.000009%		Not Available
Missed labour	18.07.03.004	0.000009%		Not Available
Mouth breathing	22.02.01.037	0.000013%		Not Available
Mucosal disorder	08.01.06.029	-	-	Not Available
Myelosuppression	01.03.03.015	0.000022%		Not Available
Nasal discharge discolouration	22.12.03.011	-	-	Not Available
Near death experience	19.10.05.007; 17.02.04.023	-	-	Not Available
Neuropsychological symptoms	19.07.03.010; 17.02.05.073	0.000039%		Not Available
NSAID exacerbated respiratory disease	22.03.01.027; 10.01.01.039	0.000009%		Not Available
Orbital myositis	15.05.01.014; 06.04.11.005	0.000009%		Not Available
Pelvic organ prolapse	21.07.04.016	-	-	Not Available
Periorbital swelling	06.08.03.032; 23.04.01.025; 10.01.05.025	-	-	Not Available

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