ADReCS

Pharmaceutical Information

Drug Name	Prednisone
Drug ID	BADD_D01834
Description	A synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]
Indications and Usage	Diez JJ, Iglesias P: Pharmacological therapy of Cushing's syndrome: drugs and indications. Mini Rev Med Chem. 2007 May;7(5):467-80.
Marketing Status	Prescription; Discontinued
ATC Code	A07EA03; H02AB07
DrugBank ID	DB00635
KEGG ID	C07370
MeSH ID	D011241
PubChem ID	5865
TTD Drug ID	D0IL7L
NDC Product Code	51655-355; 70934-259; 60219-1705; 50090-3330; 71329-107; 80425-0069; 0527-2932; 63629-7917; 68071-2661; 61919-226; 0054-0018; 58118-0173; 50090-3336; 66267-173; 53002-3520; 59651-485; 61919-326; 42291-771; 75987-022; 71335-0464; 63629-2254; 63739-588; 70518-2676; 68071-4319; 60687-145; 67296-1183; 68071-5196; 53002-3250; 0603-5337; 53002-3092; 75987-021; 0054-8724; 51655-208; 68788-9309; 59651-489; 70954-060; 60219-1708; 69668-220; 51655-701; 66267-171; 55700-208; 63629-2264; 0527-2931; 63629-7753; 71335-1628; 64380-783; 60219-1707; 70954-057; 0591-5443; 42708-105; 66267-812; 0615-8395; 70934-218; 76420-067; 51655-726; 59746-175; 55700-209; 0527-2930; 71610-641; 50090-4428; 63629-8119; 63629-2260; 0527-2935; 53002-3252; 68071-4491; 42708-115; 0054-4742; 51407-360; 61919-235; 71335-0857; 80425-0106; 71335-1516; 67296-1419; 50090-2608; 82298-103; 50090-1990; 68071-5242; 68071-4685; 42291-769; 75987-020; 68788-8116; 68788-9551; 67296-1194; 71335-1915; 43063-866; 67544-399; 71205-407; 67296-0974; 68788-8108; 50090-4784; 70934-101; 0527-2934; 42708-136; 58118-5442; 60219-1706; 13672-031; 0591-5442; 51407-359; 63629-2261; 59651-487; 71335-0856; 63629-4562; 42291-768; 70518-1854; 63629-1587; 67296-0138; 70954-058; 55154-4949; 43063-703; 68071-2578; 68071-2304; 0054-9818; 71335-1220; 63629-2435; 70518-0306; 50090-1989; 71205-362; 71335-0623; 49999-028; 42291-770; 55700-203; 0054-8739; 61919-404; 70518-2703; 51407-355; 71335-1736; 71205-089; 68071-4903; 70518-2115; 80425-0105; 63187-243; 0054-3722; 70518-2314; 0054-9828; 68071-2445; 0395-8165; 50090-4785; 38779-0154; 63187-085; 70954-061; 50090-5657; 0143-9740; 68788-7692; 63187-037; 61919-108; 70518-2916; 50090-0439; 63629-1579; 71335-1285; 0904-6923; 61919-321; 42708-045; 0603-5336; 70882-117; 70518-0073; 68788-7281; 72189-275; 63187-807; 70954-059; 70518-1120; 67296-1203; 50090-1001; 50090-5814; 63629-2257; 60760-615; 67296-1065; 55154-4946; 59651-486; 67296-1083; 71335-0508; 68071-3143; 0143-9739; 50090-5660; 70934-831; 51552-0028; 63629-2259; 71335-1926; 60687-122; 70934-137; 64380-782; 43063-911; 0378-0640; 67296-1704; 55289-330; 71335-0651; 68071-2594; 50090-5656; 50090-0098; 71335-1780; 67296-0140; 50090-2532; 68071-5195; 0054-4728; 63629-2263; 50090-2786; 72189-246; 50090-3137; 42708-114; 54348-506; 68071-2500; 71329-105; 0615-0536; 0054-0019; 70518-2704; 71335-1524; 70934-096; 0904-7127; 68071-2209; 63187-997; 53002-3091; 71335-1629; 71335-1737; 63629-2258; 0527-2933; 55154-8130; 59651-484; 42291-727; 50090-0102; 51407-357; 59746-173; 68788-7637; 71335-0335; 0615-8307; 68071-2511; 68071-4862; 70934-699; 59746-172; 70934-674; 67296-1331; 68071-4691; 60760-255; 50090-1455; 71335-1525; 71205-460; 76420-068; 61919-373; 63629-2262; 59651-488; 0603-5339; 51407-358; 0603-5338; 76420-069; 70934-095; 68788-7752; 50090-3361; 0378-0642; 50090-1991; 71335-2051; 59746-171; 53002-0610; 0054-8740; 63187-020; 0615-3593; 67296-1755; 0603-5335; 72789-235; 0615-8306; 70518-3401; 71205-537; 70518-3138; 0615-8391; 64380-785; 60760-002; 70954-056; 57582-003; 68788-7372; 63187-300; 55154-4950; 68071-4850; 68071-2509; 0054-9817; 71205-239; 50090-5202; 0054-0017; 68071-1777; 55154-4938; 13672-033; 0591-5052; 71205-421; 71329-104; 61919-365; 45865-638; 0378-0641; 64380-835; 71329-108; 0143-9738; 70518-1561; 64380-784; 50090-5453; 71329-106; 60760-932; 70518-2138; 70518-3142; 63629-2255; 63629-2256; 13672-032; 60687-134; 63187-066; 63629-1605; 64958-0002; 50090-2789; 60760-715; 68788-6440; 50090-0097; 53002-3090; 70518-2675; 68071-1779; 66267-860; 66267-172; 43063-968; 63629-2434; 50090-5816; 71205-403; 43353-657; 51407-356; 0054-4741; 63629-8015; 67296-1767; 68788-8166; 67296-0247; 60722-1002; 45865-670; 70518-0307; 70518-0305; 71329-103; 49452-6000
Synonyms	Prednisone \| Dehydrocortisone \| delta-Cortisone \| Rectodelt \| Prednison Hexal \| Sterapred \| Ultracorten \| Winpred \| Apo-Prednisone \| Cortan \| Cortancyl \| Panafcort \| Cutason \| Decortin \| Dacortin \| Decortisyl \| Deltasone \| Encortone \| Encorton \| Enkortolon \| Kortancyl \| Liquid Pred \| Meticorten \| Orasone \| Panasol \| Predni Tablinen \| Prednidib \| Predniment \| Prednison Acsis \| Acsis, Prednison \| Pronisone \| Sone \| Prednison Galen

Chemical Information

Molecular Formula	C21H26O5
CAS Registry Number	53-03-2
SMILES	CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
Chemical Structure

ADR Related Proteins Induced by Drug

ADR Term	Protein Name	UniProt AC	TTD Target ID	PMID
Not Available	Not Available	Not Available	Not Available	Not Available

ADRs Induced by Drug

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Acute graft versus host disease in intestine	10.02.01.051; 12.02.09.020; 07.11.01.019	0.000010%		Not Available
Stress cardiomyopathy	24.04.04.026; 02.04.01.012	0.000060%		Not Available
Human herpesvirus 8 infection	11.05.02.033; 10.03.03.008	0.000179%		Not Available
Velopharyngeal incompetence	07.05.01.020; 22.04.05.020	0.000060%		Not Available
Vasogenic cerebral oedema	17.07.02.008	0.000040%		Not Available
Abdominal wall haematoma	24.07.02.039; 07.16.05.005	0.000080%		Not Available
Trichophytosis	23.09.02.016; 11.03.08.007	0.000026%		Not Available
Pneumonia cryptococcal	22.07.08.012; 11.03.04.005	0.000060%		Not Available
Skin plaque	23.03.03.044	0.000179%		Not Available
Graft versus host disease in lung	22.01.01.021; 12.02.09.030; 10.02.01.061	0.000016%		Not Available
Malacoplakia gastrointestinal	11.07.01.017; 07.08.03.016	0.000040%		Not Available
C-reactive protein abnormal	13.09.01.023	0.000040%		Not Available
Cerebellar ischaemia	24.04.06.033; 17.08.01.047	0.000040%		Not Available
Phaeochromocytoma crisis	16.24.02.007; 05.01.04.008	0.000021%		Not Available
Burkholderia cepacia complex infection	11.02.27.001	0.000031%		Not Available
Inflammatory marker increased	13.09.02.003	0.000040%		Not Available
Clostridium test positive	13.08.01.007	0.000080%		Not Available
Infective pulmonary exacerbation of cystic fibrosis	22.03.01.023; 11.01.09.016	0.000040%		Not Available
Exposed bone in jaw	15.02.04.034	0.000060%		Not Available
Mycobacterium chelonae infection	11.04.02.005	0.000179%		Not Available
Epstein-Barr virus associated lymphoma	16.28.01.003; 11.05.10.007; 01.15.01.003	0.000010%		Not Available
Infectious pleural effusion	22.05.01.004; 11.01.09.011	0.000060%		Not Available
Spinal pain	17.10.01.020; 15.02.01.008; 08.01.08.030	0.000100%		Not Available
Glucocorticoid deficiency	14.11.01.037; 05.01.02.011	0.000119%		Not Available
Bandaemia	01.02.01.015	0.000040%		Not Available
Skin wound	23.03.11.022; 12.01.06.015	0.000040%		Not Available
Autoinflammatory disease	10.02.07.001; 08.05.02.012	0.000040%		Not Available
Prerenal failure	24.06.02.025; 20.01.03.022	0.000016%		Not Available
Intestinal fibrosis	07.13.01.013	0.000060%		Not Available
Septic vasculitis	24.05.02.025; 23.06.01.014; 11.01.11.017	0.000060%		Not Available

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