ADReCS

Pharmaceutical Information

Drug Name	Prednisone
Drug ID	BADD_D01834
Description	A synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]
Indications and Usage	Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.[L10502]
Marketing Status	approved; vet_approved
ATC Code	A07EA03; H02AB07
DrugBank ID	DB00635
KEGG ID	D00473
MeSH ID	D011241
PubChem ID	5865
TTD Drug ID	D0IL7L
NDC Product Code	80425-0068; 82982-041; 0591-5052; 42291-727; 42708-105; 43063-911; 50090-0439; 50090-3361; 51655-242; 53002-0610; 55154-4950; 58118-0173; 59746-175; 60219-1707; 61919-321; 62135-471; 63187-066; 63629-2255; 63629-2263; 0378-0642; 64380-949; 67296-0138; 67296-1194; 67296-1755; 68071-2304; 68071-5242; 70518-0632; 70518-2115; 70518-2138; 71205-729; 71205-755; 71205-818; 0054-4741; 71335-1926; 0591-5443; 71335-2153; 0603-5336; 76420-068; 80425-0069; 82982-042; 10135-777; 10135-779; 50090-3137; 51655-493; 51655-763; 51655-765; 51655-779; 55154-4938; 59746-171; 60760-932; 63187-807; 63629-2254; 63629-2434; 64380-835; 66267-173; 66267-860; 67296-1444; 68071-2661; 68071-4691; 68071-5195; 68788-7372; 68788-7692; 68788-8166; 68788-9551; 70518-2675; 70518-2704; 70518-3540; 70934-880; 70954-060; 71205-741; 71335-2088; 0054-8739; 72162-1169; 72189-275; 0615-8438; 80425-0105; 64958-0002; 43063-968; 50090-6225; 51655-410; 51655-988; 53002-3090; 54348-506; 55154-4946; 55289-330; 55700-208; 60219-1705; 61919-235; 61919-365; 63629-7917; 67296-0140; 0054-0019; 68788-8212; 70954-061; 71205-089; 71335-1780; 71335-2149; 0054-8724; 0054-8740; 0054-9828; 72162-1170; 0615-8307; 0615-8441; 59651-489; 60760-002; 63629-2256; 64380-782; 67296-1183; 0054-0018; 70518-1553; 70518-2916; 70934-095; 70954-057; 71205-460; 71205-797; 71335-2122; 71335-2134; 0603-5337; 71610-721; 0054-9818; 0615-8306; 72189-489; 0615-8439; 80425-0106; 0904-6923; 13672-033; 10135-778; 43063-703; 45865-670; 53002-3252; 59746-172; 60687-145; 60760-255; 60760-790; 61919-108; 63187-085; 63629-2258; 63629-2435; 0378-0641; 68071-2209; 68071-2578; 68071-3143; 68788-6440; 68788-7752; 68788-8267; 70954-059; 71205-537; 71335-1524; 71335-1628; 71335-1736; 71335-1737; 71335-2051; 0603-5335; 0603-5339; 0615-8440; 75987-021; 75987-022; 0591-5442; 13672-032; 42708-115; 50090-3336; 51655-355; 51655-416; 51655-935; 51655-972; 59651-487; 60219-1708; 62135-470; 63187-300; 63187-997; 63629-2260; 63629-2262; 68071-1779; 68788-8116; 0527-2934; 70518-0305; 70518-0306; 70518-1120; 70882-117; 0054-4742; 71335-1516; 71335-1525; 0603-5338; 76420-067; 13672-031; 51552-0028; 10135-774; 42708-136; 50090-6123; 50090-6259; 51655-068; 51655-359; 51655-701; 53002-3091; 53002-3520; 59651-488; 60687-122; 63187-243; 63629-1579; 63629-2261; 0378-0640; 64380-784; 64380-785; 67296-0247; 67296-1065; 67296-1455; 67296-1457; 68071-2696; 68071-5196; 68071-5233; 0527-2933; 70518-1561; 70518-2676; 70518-3138; 71205-403; 71335-0464; 0615-8395; 72789-235; 0904-7127; 42708-167; 50090-3330; 50090-3354; 50090-5816; 51407-356; 51407-360; 51655-726; 55154-4949; 59651-484; 60760-715; 63629-2257; 68071-2781; 68788-8184; 0527-2930; 70518-0307; 70518-2555; 70518-3142; 70934-096; 70954-056; 71205-407; 71335-0623; 0054-4728; 0054-9817; 72162-1171; 75987-020; 10135-776; 60722-1002; 82298-103; 42291-771; 42708-114; 42708-166; 51655-349; 51655-760; 59651-486; 59746-173; 60219-1706; 60760-615; 63187-037; 67296-1083; 67296-1446; 67544-399; 0054-0017; 70518-3537; 70934-291; 0054-3722; 71205-362; 71335-0335; 71335-0508; 71335-2079; 71610-641; 72162-1172; 72189-246; 80425-0193; 38779-0154; 57582-003; 42708-045; 43063-866; 50090-6122; 51407-355; 51407-357; 51655-197; 51655-541; 51655-716; 53002-3250; 55700-203; 55700-209; 60687-134; 61919-326; 63187-020; 63629-1605; 63629-2259; 63629-2264; 63739-588; 64380-783; 67296-1203; 67296-1767; 67296-1886; 68071-2771; 70518-2314; 70518-2703; 70518-3401; 70518-3476; 70518-3539; 70518-3555; 70954-058; 71205-239; 71205-421; 71205-665; 71335-1915; 71335-2069; 71335-2160; 71335-9715; 72189-430; 0615-8391; 76420-069; 49452-6000; 10135-775; 42291-770; 42291-783; 50090-4785; 50090-5814; 50090-6376; 51407-358; 51407-359; 51655-208; 51655-939; 55154-3564; 58118-5442; 59651-485
UNII	VB0R961HZT
Synonyms	Prednisone \| Dehydrocortisone \| delta-Cortisone \| Rectodelt \| Prednison Hexal \| Sterapred \| Ultracorten \| Winpred \| Apo-Prednisone \| Cortan \| Cortancyl \| Panafcort \| Cutason \| Decortin \| Dacortin \| Decortisyl \| Deltasone \| Encortone \| Encorton \| Enkortolon \| Kortancyl \| Liquid Pred \| Meticorten \| Orasone \| Panasol \| Predni Tablinen \| Prednidib \| Predniment \| Prednison Acsis \| Acsis, Prednison \| Pronisone \| Sone \| Prednison Galen

Chemical Information

Molecular Formula	C21H26O5
CAS Registry Number	53-03-2
SMILES	CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Diabetic metabolic decompensation	14.07.03.003; 05.07.03.003	0.000009%		Not Available
Spontaneous haemorrhage	24.07.01.081; 01.01.03.007	-	-	Not Available
Phospholipidosis	14.08.04.025	0.000009%		Not Available
Pulmonary pain	22.12.01.010	-	-	Not Available
Graft versus host disease in gastrointestinal tract	10.02.01.059; 12.02.09.028; 07.11.01.027	0.000009%		Not Available
Internal haemorrhage	24.07.01.072	-	-	Not Available
Soft tissue sarcoma	16.33.01.003; 15.09.03.021	0.000018%		Not Available
Lower respiratory tract congestion	22.12.01.004	-	-	Not Available
Gastrointestinal wall thickening	07.01.06.032	0.000029%		Not Available
Macular detachment	06.09.03.020	0.000009%		Not Available
Fine motor skill dysfunction	17.01.02.020	0.000013%		Not Available
Steatohepatitis	14.08.04.020; 09.01.07.024	0.000031%		Not Available
Gluten sensitivity	14.02.01.008; 10.01.01.031; 07.17.01.009	0.000046%		Not Available
Pharyngeal paraesthesia	22.04.05.018; 17.02.06.035	-	-	Not Available
Vein rupture	24.03.02.032; 12.01.11.011	-	-	Not Available
Hyperinsulinaemic hypoglycaemia	14.06.03.010; 05.06.03.010	0.000018%		Not Available
Non-cirrhotic portal hypertension	24.08.06.003; 09.01.06.019	0.000018%		Not Available
End stage renal disease	20.01.03.019	0.000085%		Not Available
Anal stenosis	07.13.05.004	0.000009%
Attention deficit hyperactivity disorder	19.21.04.004	0.000009%		Not Available
Bell's palsy	17.04.03.011	-	-	Not Available
Biliary obstruction	09.02.02.005	-	-	Not Available
Birdshot chorioretinopathy	06.04.06.014; 10.04.04.025	0.000013%		Not Available
Blood loss anaemia	24.07.01.088; 01.03.02.018	0.000009%		Not Available
Cardiac sarcoidosis	02.04.02.038; 10.02.06.004	0.000009%		Not Available
Central nervous system vasculitis	24.12.04.005; 17.08.02.029; 10.02.02.030	0.000022%		Not Available
Cerebral venous sinus thrombosis	24.01.04.021; 17.08.03.006	0.000040%		Not Available
Chronic graft versus host disease oral	12.02.09.034; 10.02.01.072; 07.11.01.033	0.000009%		Not Available
Chronic rhinosinusitis with nasal polyps	16.38.01.003; 22.04.06.007	0.000009%		Not Available
Colorectal adenoma	16.05.02.009; 07.20.01.019	0.000040%		Not Available

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