Pharmaceutical Information |
Drug Name |
Prednicarbate |
Drug ID |
BADD_D01830 |
Description |
Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as [hydrocortisone]. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness. |
Indications and Usage |
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. |
Marketing Status |
Prescription |
ATC Code |
D07AC18 |
DrugBank ID |
DB01130
|
KEGG ID |
D05601
|
MeSH ID |
C035287
|
PubChem ID |
52421
|
TTD Drug ID |
D09IEE
|
NDC Product Code |
63592-2140; 0168-0410; 65089-0032; 24002-0006; 52128-168 |
Synonyms |
prednicarbate | prednisolone-17-ethylcarbonate-21-propionate | Peitel | HOE 777 | HOE-777 | Batmen | Dermatop |
|
Chemical Information |
Molecular Formula |
C27H36O8 |
CAS Registry Number |
73771-04-7 |
SMILES |
CCC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)OC(=O)OCC |
Chemical Structure |
|
|
ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
|
ADRs Induced by Drug |
|