Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Piroxicam
Drug ID BADD_D01784
Description A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
Indications and Usage For treatment of osteoarthritis and rheumatoid arthritis.
Marketing Status Prescription; Discontinued
ATC Code M01AC01; M02AA07; S01BC06
DrugBank ID DB00554
KEGG ID D00127
MeSH ID D010894
PubChem ID 54676228
TTD Drug ID D00IBN
NDC Product Code 22365-114; 59762-0145; 53747-044; 72789-210; 0395-8163; 0143-3107; 0069-3220; 59762-0140; 59348-0014; 46438-0053; 68981-041; 71205-032; 0069-3230; 60592-604; 17337-0538; 60715-3270; 29300-255; 0143-3108; 61919-193; 29300-256; 51927-0145; 29033-012; 46438-0639; 64380-842; 38779-0302; 0093-0756; 42543-115; 72789-211; 42571-176; 42571-177; 49452-5476; 42291-677; 70771-1430; 42291-674; 29033-013; 50090-4779; 51927-1699; 70771-1429; 0093-0757; 63629-9150; 62991-1113; 55700-697; 64380-843; 71335-1999; 63629-9148; 63629-9149; 71205-203; 42543-114; 61919-188; 63187-972
Synonyms Piroxicam | CP-16171 | CP 16171 | CP16171 | Feldene
Chemical Information
Molecular Formula C15H13N3O4S
CAS Registry Number 36322-90-4
SMILES CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Hepatic function abnormalGlycogen [starch] synthase, muscleP13807Not Available1338186; 7733654; 6416813; 6766890; 237970; 7575414; 3105560; 6096366
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eosinophilia01.02.04.001--
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.003--
Erythema23.03.06.0010.006450%Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.004300%
Eye irritation06.04.05.003--Not Available
Eye swelling06.08.03.003--Not Available
Face oedema10.01.05.002; 08.01.07.003; 23.04.01.0040.006450%
Faeces discoloured07.01.03.0020.001683%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.004300%Not Available
Fixed drug eruption23.03.05.006; 10.01.01.022; 08.01.06.0170.017200%Not Available
Flatulence07.01.04.002--
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gait disturbance17.02.05.016; 08.01.02.0020.004300%
Gastric ulcer07.04.03.0020.015050%
Gastritis07.08.02.001--
Gastrointestinal disorder07.11.01.0010.004300%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.003926%Not Available
Gastrointestinal pain07.01.05.005--
Glomerulonephritis20.05.01.001; 10.02.01.006--Not Available
Glossitis07.14.01.001--Not Available
Haematemesis24.07.02.011; 07.12.02.0020.010750%Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.0030.004300%Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
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