Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pirfenidone
Drug ID BADD_D01783
Description Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Indications and Usage For the treatment of idiopathic pulmonary fibrosis (IPF).
Marketing Status Prescription; Discontinued
ATC Code L04AX05
DrugBank ID DB04951
KEGG ID D01583
MeSH ID C093844
PubChem ID 40632
TTD Drug ID D02WCI
NDC Product Code 65372-1197; 46708-907; 73309-052; 46016-5310; 62207-004; 62512-0070; 69037-0013; 53104-7712; 11014-0214; 59285-013; 76072-1006; 69766-030; 50242-122; 57297-140; 46016-5312; 46438-0648; 60219-1642; 50242-121; 50242-123; 59651-199; 60219-1640; 60219-1641; 60862-005; 42571-329; 63759-7005
Synonyms pirfenidone | 5-methyl-1-phenyl-2-(1H)-pyridone | Esbriet | deupirfenidone | 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one | Deskar
Chemical Information
Molecular Formula C12H11NO
CAS Registry Number 53179-13-8
SMILES CC1=CN(C(=O)C=C1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.0010.006369%Not Available
Hepatitis09.01.07.0040.005211%Not Available
Hepatitis acute09.01.07.0050.002895%Not Available
Hepatocellular injury09.01.07.008--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.012738%Not Available
Hernia08.01.04.0010.001158%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.008106%
Hiatus hernia22.09.02.004; 07.16.01.0010.005790%Not Available
Hiccups22.02.04.002; 07.01.06.0090.001158%
Hip fracture12.04.01.001; 15.08.03.0010.003474%
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.0030.001737%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hyperkeratosis23.01.01.0010.001158%
Hypersensitivity10.01.03.003--
Hypersomnia19.02.05.001; 17.15.01.0010.003474%
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypocoagulable state01.01.02.0040.001158%Not Available
Hypogeusia17.02.07.004; 07.14.03.0020.001158%Not Available
Hyponatraemia14.05.04.002--
Hypopnoea22.02.01.0210.001158%Not Available
Hypotension24.06.03.002--
Hypoventilation22.02.01.0070.000302%Not Available
Hypoxia22.02.02.0030.002417%
Idiopathic pulmonary fibrosis22.01.02.014; 10.02.01.0340.007401%Not Available
Impaired gastric emptying07.02.02.0040.001158%
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
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