Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Physostigmine
Drug ID BADD_D01768
Description A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Indications and Usage For the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.
Marketing Status Not Available
ATC Code S01EB05; V03AB19
DrugBank ID DB00981
KEGG ID D00196
MeSH ID D010830
PubChem ID 5983
TTD Drug ID D09JVV
NDC Product Code Not Available
Synonyms Physostigmine | Eserine
Chemical Information
Molecular Formula C15H21N3O2
CAS Registry Number 57-47-6
SMILES CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AstheniaCholinesteraseP06276T9979911475943; 9880090; 16437532; 10090427
DiarrhoeaCholinesteraseP06276T9979911475943; 9880090; 16437532; 10090427
DizzinessCholinesteraseP06276T9979911475943; 9880090; 16437532; 10090427
NauseaAcetylcholinesteraseP22303T3008211475943; 9880090; 16437532; 10090427
VomitingCholinesteraseP06276T9979911475943; 9880090; 16437532; 10090427
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bradycardia02.03.02.002--Not Available
Nausea07.01.07.001--
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.001--
Vomiting07.01.07.003--
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