Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phenylephrine hydrochloride
Drug ID BADD_D01763
Description Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.[A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.[A187376] Phenylephrine was granted FDA approval in 1939.[L9413]
Indications and Usage Phenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.
Marketing Status Prescription
ATC Code C01CA06; R01AA04; R01AB01; R01BA03; S01FB01; S01GA05
DrugBank ID DB00388
KEGG ID D00511
MeSH ID D010656
PubChem ID 5284443
TTD Drug ID D0O6IU
NDC Product Code 81522-094; 63323-751; 0904-6753; 70121-1578; 36800-648; 68210-4196; 70121-1579; 63029-401; 70121-1577; 62331-028; 55154-8226; 71872-7267; 68210-1210; 59779-838; 50580-437; 71872-7043; 71872-7273; 53592-221; 61990-0212; 41520-729; 71872-7231; 24385-390; 72572-571; 57218-810; 57344-131; 47682-161; 16729-466; 55910-802; 0363-0717; 61990-0211; 71872-7042; 51927-1225; 0113-7094; 65145-115; 37808-209; 47682-809; 38779-0247; 36800-331; 0363-0648; 53304-0306; 0781-3466; 62579-550; 47682-990; 55150-300; 16729-465; 12538-0103; 41250-231; 0113-2004; 55150-302; 30142-539; 63868-697; 81284-211; 37012-094; 62011-0085; 36800-094; 0781-3458; 11822-0990; 72572-570; 54871-0092; 49035-131; 69790-161; 53943-131; 42702-102; 55910-094; 64431-0001; 70069-802; 71872-7159; 0781-3422; 49348-700; 0113-0648; 0225-0805; 70000-0132; 37808-728; 69842-569; 62579-546; 56062-094; 62991-2046; 69842-443; 68083-338; 55910-276; 36800-631; 63029-403; 42023-215; 50090-4515; 0225-0800; 51754-4010; 0395-8122; 41250-648; 16729-464; 0641-6229; 41163-648; 50090-4514; 51552-0232; 50580-546; 71288-808; 41520-094; 42961-054; 51662-1576; 70069-801; 72036-131; 0225-0810; 62011-0077; 46122-149; 50090-3659; 47682-017; 63941-331; 41415-728; 58809-940; 65145-116; 59779-390; 55150-301; 50580-784; 70594-065; 58747-0502; 59779-094; 55670-163; 0781-9226; 11673-204; 51754-4020; 14037-9999; 71863-202; 52584-577; 81284-212; 25021-315; 51754-4000; 68083-465; 49452-5291; 0113-0094; 76014-004; 49348-197; 46122-689; 0781-9227; 0067-2086; 0363-0390; 70594-064; 73408-990; 0641-6188; 70069-803; 69842-648; 24385-603; 0781-9228; 17478-201; 70000-0506; 61990-0213; 81522-648; 49035-648; 65145-117; 68083-339; 70594-063; 42023-214; 0641-6189; 47682-162; 68998-131; 0404-9931; 72288-094; 81284-213; 41520-831; 0641-6142; 49452-5290; 68210-4172; 71288-807; 0363-2023; 21130-728; 42702-103; 17478-206
Synonyms Phenylephrine | (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol | Metasympatol | Mezaton | Phenylephrine Hydrochloride | Phenylephrine Tannate | Tannate, Phenylephrine | Metaoxedrin | Neo-Synephrine | Neo Synephrine | Neosynephrine
Chemical Information
Molecular Formula C9H13NO2.ClH
CAS Registry Number 61-76-7
SMILES CNCC(C1=CC(=CC=C1)O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia02.03.02.001--Not Available
Blood pressure increased13.14.03.005--Not Available
Death08.04.01.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Subarachnoid haemorrhage12.01.10.011; 24.07.04.004; 17.08.01.010--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
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