Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phentermine hydrochloride
Drug ID BADD_D01757
Description Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.[A174370] Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential).[A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to obtain the desired effect.[A174373]
Indications and Usage For the treatment and management of obesity.
Marketing Status Prescription; Discontinued
ATC Code A08AA01
DrugBank ID DB00191
KEGG ID D05459
MeSH ID D010645
PubChem ID 70969
TTD Drug ID D0U0RZ
NDC Product Code 0527-1308; 11534-160; 63629-1041; 66022-0112; 0527-1310; 0185-5000; 71335-0564; 0527-1445; 55289-791; 50436-6744; 50090-1534; 71335-0474; 71335-1312; 68788-9271; 72789-175; 63629-1107; 72189-301; 51224-202; 68071-2640; 63629-2389; 70518-3407; 11534-159; 57844-019; 57844-140; 63629-2387; 61919-557; 68788-7972; 63629-2384; 43063-646; 71205-250; 70518-2278; 63629-7122; 43063-961; 68788-7740; 43547-404; 53489-676; 63629-2388; 55289-624; 63629-8201; 43063-654; 72189-253; 10702-067; 50436-0250; 72189-071; 43063-596; 55289-701; 71335-0419; 10702-029; 10702-001; 76420-108; 10702-026; 64980-190; 63629-1108; 50090-2536; 0792-0344; 10702-028; 63187-987; 61919-186; 63629-2477; 72189-203; 0527-1742; 11534-157; 50090-1498; 43063-182; 63629-1042; 63629-1106; 68788-7823; 10702-025; 42806-810; 11534-176; 68788-8942; 63187-800; 70934-474; 50090-0416; 0185-0644; 50436-0101; 65319-1452; 72789-208; 50090-0415; 43063-437; 71335-1591; 50090-3992; 63629-1043; 68788-8950; 68071-3241; 63629-1045; 71335-0678; 53002-7931; 71335-0161; 71335-0030; 63629-5075; 51927-2937; 63187-515; 63629-2383; 10702-027; 50090-1499; 63187-512; 13107-105; 71335-0350; 71335-1933; 68382-704; 13107-061; 50090-5493; 50090-3535; 71335-1860; 71205-564; 71335-0646; 0792-0345; 64850-810; 50090-4216; 68788-7906; 76420-057; 63629-2949; 63629-2385; 0527-1743; 50090-0653; 0527-0597; 63629-2386; 51224-203; 38779-0854; 50090-1679; 17337-0030; 66267-166; 63629-8528; 51224-101; 68071-4919; 50436-0202; 63629-4385; 63629-3211; 70771-1201; 13107-106; 63629-1040; 68382-703; 50090-3282; 63629-7874; 42806-524; 63629-8152; 63629-8537; 71205-340; 68382-670; 63629-1044; 70771-1202; 0527-1438; 45865-556; 70771-1200
Synonyms Phentermine | Duromine | Phentermine Hydrochloride | Hydrochloride, Phentermine | Adipex-P | Adipex P | AdipexP | Ionamine
Chemical Information
Molecular Formula C10H16ClN
CAS Registry Number 1197-21-3
SMILES CC(C)(CC1=CC=CC=C1)N.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood pressure increased13.14.03.005--Not Available
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dysphoria19.04.02.004--Not Available
Euphoric mood19.04.02.006--
Headache17.14.01.001--
Insomnia19.02.01.002; 17.15.03.002--
Palpitations02.01.02.003--
Restlessness19.11.02.002; 17.02.05.021--
Tachycardia02.03.02.007--Not Available
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Withdrawal syndrome19.07.02.005; 08.06.02.012--Not Available
Ischaemic cardiomyopathy24.04.04.019; 02.04.01.004--Not Available
Libido disorder21.03.02.006; 19.08.03.004--Not Available
Cardiac valve disease02.07.02.001--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Psychotic disorder19.03.01.002--
Pulmonary arterial hypertension24.08.03.003; 22.06.01.002--Not Available
Device stimulation issue27.01.02.005--Not Available
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