Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phendimetrazine
Drug ID BADD_D01748
Description Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970.
Indications and Usage Used in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.
Marketing Status Prescription; Discontinued
ATC Code Not Available
DrugBank ID DB01579
KEGG ID D08347
MeSH ID C100294
PubChem ID 30487
TTD Drug ID D0T6SU
NDC Product Code 51655-005
Synonyms phendimetrazine | X-Trozine | Di-Ap-Trol | Dyrexan | Hyrex | Melfiat | Obezine | phendimetrazine hydrochloride | phendimetrazine hydrochloride, (2S-trans)-isomer | phendimetrazine tartrate | phendimetrazine tartrate, (2S-trans(R-(R*,R*)))-isomer | phendimetrazine tartrate, (R-(R*,R*))-isomer | phendimetrazine, (2R-cis)-isomer | phendimetrazine, (2S-trans)-isomer | phendimetrazine, trans(+-)-isomer | Prelu-2 | Trimstat | Wehless | Weightrol | Adipost | Bontril
Chemical Information
Molecular Formula C12H17NO
CAS Registry Number 634-03-7
SMILES CC1C(OCCN1C)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Agitation19.06.02.001; 17.02.05.012--
Blood pressure increased13.14.03.005--Not Available
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug abuse19.07.02.010--Not Available
Dysuria20.02.02.002--
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Insomnia19.02.01.002; 17.15.03.002--
Nausea07.01.07.001--
Palpitations02.01.02.003--
Pollakiuria20.02.02.007--
Tachycardia02.03.02.007--Not Available
Tremor17.01.06.002--
Vision blurred17.17.01.010; 06.02.06.007--
Cardiac valve disease02.07.02.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Psychotic disorder19.03.01.002--
Pulmonary arterial hypertension24.08.03.003; 22.06.01.002--Not Available
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