Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Perampanel
Drug ID BADD_D01733
Description Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.
Indications and Usage Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.
Marketing Status Prescription
ATC Code N03AX22
DrugBank ID DB08883
KEGG ID D08964
MeSH ID C551441
PubChem ID 9924495
TTD Drug ID D0U3ED
NDC Product Code 62856-278; 62856-272; 50379-0020; 62856-276; 67835-0026; 60510-609; 11071-907; 11071-906; 11071-905; 60510-606; 11071-902; 62856-274; 60510-605; 11071-904; 60510-608; 60510-604; 47848-049; 62856-280; 62856-282; 60510-607; 11071-903; 62856-290
Synonyms perampanel | 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one | perampanel hydrate | perampanel hydrate (4:3) | E-2007 | E2007 | ER-155055-90 | Fycompa
Chemical Information
Molecular Formula C23H15N3O
CAS Registry Number 380917-97-5
SMILES C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Aggression19.05.01.001--Not Available
Anger19.04.02.001--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Back pain15.03.04.005--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Cough22.02.03.001--
Diplopia06.02.06.002; 17.17.01.005--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dysarthria19.19.03.001; 17.02.08.001--
Ear disorder04.03.01.001--Not Available
Euphoric mood19.04.02.006--
Eye disorder06.08.03.001--Not Available
Fall12.01.08.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gastrointestinal disorder07.11.01.001--Not Available
Head injury12.01.09.003--Not Available
Headache17.14.01.001--
Hypersomnia17.15.01.001; 19.02.05.001--
Hypoaesthesia17.02.06.023--Not Available
Hyponatraemia14.05.04.002--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
The 1th Page    1 2 3    Next   Last    Total 3 Pages