| Drug Name |
Pentoxifylline |
| Drug ID |
BADD_D01731 |
| Description |
Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties.[A226415, L30300] Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated for its possible use in diverse conditions, including osteoradionecrosis, diabetic kidney disease, and generally any condition associated with fibrosis.[A226410, A226415, A226455] More recently, PTX has been suggested as a possible treatment for COVID-19-induced pulmonary complications due to its ability to regulate the production of inflammatory cytokines.[A226608]
Pentoxifylline has been marketed in Europe since 1972; PTX extended-release tablets sold under the trade name TRENTAL by US Pharm Holdings were first approved by the FDA on Aug 30, 1984, but have since been discontinued. A branded product, PENTOXIL, marketed by Upsher-Smith Laboratories, and generic forms marketed by Valeant Pharmaceuticals and APOTEX have been available since the late 1990s.[L30300] |
| Indications and Usage |
For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
C04AD03 |
| DrugBank ID |
DB00806
|
| KEGG ID |
D00501
|
| MeSH ID |
D010431
|
| PubChem ID |
4740
|
| TTD Drug ID |
D09QEI
|
| NDC Product Code |
61281-3500; 72189-025; 0395-8071; 63629-2910; 66651-912; 68071-4532; 0615-8305; 38779-2560; 62991-2521; 60592-432; 43353-123; 0904-5448; 62756-117; 60505-0033; 51927-4389; 51552-1059; 70518-1285; 49452-5080 |
| Synonyms |
Pentoxifylline | Oxpentifylline | Trental | Pentoxil | Torental | Agapurin | BL-191 | BL 191 | BL191 |
