Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pemetrexed
Drug ID BADD_D01701
Description Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative surgery. Its use in non-small cell lung cancer has also been investigated.
Indications and Usage Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
Marketing Status Prescription
ATC Code L01BA04
DrugBank ID DB00642
KEGG ID D07472
MeSH ID D000068437
PubChem ID 135410875
TTD Drug ID D0Y4GO
NDC Product Code 65129-1366; 42367-531; 47848-026
Synonyms Pemetrexed | MTA | N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid | Pemetrexed Disodium | Disodium, Pemetrexed | LY 231514 | 231514, LY | LY-231,514 | LY231514 | LY 231,514 | 231,514, LY | LY-231514 | Alimta
Chemical Information
Molecular Formula C20H21N5O6
CAS Registry Number 137281-23-3
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.000533%
Abdominal pain07.01.05.0020.002131%
Acute myocardial infarction24.04.04.001; 02.02.02.0010.000533%Not Available
Adenocarcinoma16.16.01.0040.000139%Not Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Anaemia01.03.02.0010.004263%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000533%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000799%Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Aphasia19.21.01.001; 17.02.03.0010.000533%
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arthralgia15.01.02.001--
Ascites02.05.04.002; 09.01.05.003; 07.07.01.0010.000799%
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.002664%Not Available
Atrial fibrillation02.03.03.0020.001865%
Back pain15.03.04.005--
Blood creatinine decreased13.13.01.003--Not Available
Blood creatinine increased13.13.01.004--
Blood pressure increased13.14.03.0050.001066%Not Available
Body temperature increased13.15.01.001--Not Available
C-reactive protein increased13.09.01.0070.000533%Not Available
Cardiac arrest02.03.04.0010.000347%
Cardiac failure02.05.01.0010.000139%
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000139%Not Available
Cellulitis11.02.01.001; 23.09.01.0010.001066%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000533%Not Available
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