Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status Prescription; Discontinued
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fracture15.08.02.001; 12.04.02.0010.001598%
Frequent bowel movements07.02.04.002--Not Available
Fungal infection11.03.05.001--Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gallbladder disorder09.03.02.001--Not Available
Gamma-glutamyltransferase increased13.03.01.0110.005062%
Gastric cancer16.13.03.001; 07.21.02.0010.000139%Not Available
Gastric haemorrhage24.07.02.007; 07.12.01.001--
Gastric ulcer07.04.03.0020.001865%
Gastric ulcer haemorrhage24.07.02.003; 07.04.03.0050.000533%Not Available
Gastritis07.08.02.0010.001598%
Gastrointestinal fistula07.11.05.001--
Gastrooesophageal reflux disease07.02.02.0030.004263%
Gastroenteritis07.19.03.001; 11.01.07.004--Not Available
Gastroenteritis viral11.05.04.005; 07.19.03.005--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal infection11.01.07.012; 07.19.02.0050.000533%Not Available
Gastrointestinal pain07.01.05.005--
Gastrointestinal perforation07.04.04.0010.000625%Not Available
Generalised oedema14.05.06.007; 08.01.07.0040.001066%
Generalised tonic-clonic seizure17.12.01.002--Not Available
Genital ulceration23.07.03.004; 21.10.05.0010.000799%Not Available
Gingival bleeding07.09.07.001; 24.07.02.0100.001332%Not Available
Gingivitis11.01.04.013; 07.09.03.003--
Glomerular filtration rate decreased13.13.01.0090.001332%Not Available
Glossitis07.14.01.0010.001332%Not Available
Glossodynia07.14.02.0010.002931%Not Available
Goitre14.11.01.008; 05.02.01.0010.000533%Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
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