Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperuricaemia14.09.01.0030.000224%
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypoalbuminaemia14.10.01.002; 09.01.02.0030.000448%
Hypocalcaemia14.04.01.0040.000336%
Hypogeusia17.02.07.004; 07.14.03.0020.000437%Not Available
Hypomagnesaemia14.04.02.001--
Hyponatraemia14.05.04.0020.001198%
Hypophosphataemia14.04.03.001--
Hypotension24.06.03.002--
Hypothyroidism05.02.03.001; 14.11.01.0120.003582%
Hypovolaemic shock24.06.02.0170.000112%Not Available
Ileal perforation07.04.06.010--
Ileus07.13.01.0010.000336%
Immune system disorder10.02.01.0010.000571%Not Available
Impaired healing08.03.02.0010.001612%Not Available
Infection11.01.08.002--Not Available
Inguinal hernia07.16.02.0010.000112%Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intermittent claudication24.04.03.0010.000112%Not Available
Interstitial lung disease22.01.02.003; 10.02.01.0330.000951%Not Available
Intestinal obstruction07.13.01.002--Not Available
Intestinal perforation07.04.06.0020.001175%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.002787%Not Available
Jaundice cholestatic09.01.01.0050.000336%Not Available
Joint swelling15.01.02.004--Not Available
Large intestine perforation12.02.03.005; 07.04.06.0050.000392%
Left ventricular failure02.05.02.0010.000168%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukoderma23.05.02.001--Not Available
Leukoencephalopathy17.13.02.0030.000112%
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