Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status Prescription; Discontinued
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
C-reactive protein increased13.09.01.0070.003730%Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.0090.000347%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.0010.003058%
Cardiac failure acute02.05.01.0050.000695%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac hypertrophy02.04.02.0170.000533%Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cardiomegaly02.04.02.001--Not Available
Cardiomyopathy02.04.01.0010.001598%Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cheilitis23.03.03.025; 07.05.01.0010.000533%
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.016--
Cholangitis09.02.01.0020.000533%Not Available
Cholecystitis09.03.01.0010.001598%
Cholecystitis acute09.03.01.0030.000208%Not Available
Cholelithiasis09.03.01.002--Not Available
Cholestasis09.01.01.0010.004529%Not Available
Chromaturia20.02.01.0020.003996%
Chronic myeloid leukaemia16.01.07.001; 01.10.07.0010.000139%Not Available
Circulatory collapse24.06.02.001--Not Available
Coagulopathy01.01.02.001--Not Available
Colitis07.08.01.001--
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