Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tumour pain16.32.03.0030.001533%
Ulcer08.03.06.0010.000358%Not Available
Upper gastrointestinal haemorrhage24.07.02.024; 07.12.02.006--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Uterine cancer16.12.05.001; 21.07.02.0030.000168%Not Available
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Vasculitis24.12.04.027; 10.02.02.0060.000336%
Vena cava thrombosis24.01.10.0010.000112%Not Available
Ventricular hypertrophy02.04.02.0120.000112%Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Visual acuity reduced17.17.01.011; 06.02.10.0120.000336%
Vitreous detachment12.01.04.005; 06.09.01.0020.000224%Not Available
Vitreous floaters06.09.01.0050.001310%
Vomiting07.01.07.0030.027098%
Weight decreased13.15.01.005--
White blood cell count decreased13.01.06.012--
Xanthoma14.08.04.010; 23.03.03.0470.000381%Not Available
Xerosis08.01.03.0160.000168%Not Available
Yellow skin23.03.03.042; 09.01.01.009; 08.01.03.0460.001175%Not Available
Pneumoperitoneum07.07.01.0080.000280%Not Available
Mobility decreased17.02.05.018; 15.03.05.023; 08.01.03.030--Not Available
Cardiotoxicity02.11.01.009; 12.03.01.0070.000560%Not Available
Intracardiac thrombus24.01.05.003; 02.11.01.0170.000112%Not Available
Onychoclasis23.02.05.0050.000112%Not Available
Performance status decreased08.01.03.0420.000224%Not Available
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.0060.000246%
Brain oedema17.07.02.003; 12.01.10.0100.000336%
Weight fluctuation14.03.02.0020.000246%Not Available
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