| Drug Name |
Paroxetine hydrochloride hemihydrate |
| Drug ID |
BADD_D01681 |
| Description |
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others.[T653] It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham.[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters.[A31914] Because of its potent inhibition of serotonin reuptake, paroxetine is more likely to cause withdrawal effects upon cessation. Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class.[A31914] The controlled release formulation was designed to decrease the likelihood of nausea that is sometimes associated with paroxetine.[L7700,L7742] |
| Indications and Usage |
Labeled indications include: major depressive disorder (MDD), panic disorder with or without agoraphobia, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Unlabeled indications include: eating disorders, impulse control disorders, vasomotor symptoms of menopause, obsessive-compulsive disorder (OCD) in children, and mild dementia-associated agitation in nonpsychotic individuals. Brisdelle, which consists of paroxetine mesylate is indicated for the treatment of moderate to severe vasomotor symptoms (like hot flashes) associated with menopause. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
N06AB05 |
| DrugBank ID |
DB00715
|
| KEGG ID |
D02260
|
| MeSH ID |
D017374
|
| PubChem ID |
9843029
|
| TTD Drug ID |
D06GDY
|
| NDC Product Code |
0378-7002; 42858-705; 70518-1253; 62350-0044; 53296-0057; 71205-198; 71610-243; 55700-379; 0378-7003; 71205-527; 70518-2598; 68788-7677; 43353-544; 0615-7985; 72969-054; 43547-347; 0378-7001; 50090-4838; 70518-2376; 70518-0550; 0378-7004; 70518-2182; 43547-348; 71610-204; 71335-0675; 70518-2387; 63187-927; 43547-349; 42858-703; 43353-554; 73377-051; 50090-4207; 64220-113; 55700-503; 43547-350; 42858-707; 71335-1506; 55289-037; 53002-2174; 70934-107; 71335-0603; 55289-053 |
| Synonyms |
Paroxetine | Aropax | BRL-29060 | BRL 29060 | BRL29060 | FG-7051 | FG 7051 | FG7051 | Paroxetine Acetate | Seroxat | Paroxetine Hydrochloride Anhydrous | Paroxetine Maleate | Paroxetine, cis-(+)-Isomer | Paroxetine, cis-(-)-Isomer | Paroxetine, trans-(+)-Isomer | Paxil | Paroxetine Hydrochloride Hemihydrate | Paroxetine Hydrochloride, Hemihydrate | Paroxetine Hydrochloride |
