Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Papaverine hydrochloride
Drug ID BADD_D01671
Description An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Indications and Usage For the treatment of impotence and vasospasms.
Marketing Status Not Available
ATC Code A03AD01; G04BE02
DrugBank ID DB01113
KEGG ID D02218
MeSH ID D010208
PubChem ID 6084
TTD Drug ID D0NJ3V
NDC Product Code 0517-4010-01; 0517-4002-25
Brand Papaverine Hydrochloride [American Regent, Inc.]
Synonym Papaverine | Pavatym | Pavabid | Cerespan | Papaverine Hydrochloride | Hydrochloride, Papaverine
Chemical Information
Molecular Formula C20H21NO4.ClH
CAS Registry Number 61-25-6
SMILES COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Blood pressure increased13.14.03.005--Not Available
Cirrhosis alcoholic09.01.04.005--Not Available
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
Headache17.14.01.001--
Heart rate increased13.14.04.002--Not Available
Hepatitis09.01.07.004--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Malaise08.01.01.003--
Nausea07.01.07.001--
Rash23.03.13.001--Not Available
Respiration abnormal22.02.08.011--Not Available
Sedation17.02.04.005--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Decreased appetite14.03.01.005; 08.01.09.028--
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