Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Paclitaxel
Drug ID BADD_D01653
Description Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Indications and Usage Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
Marketing Status approved; vet_approved
ATC Code L01CD01
DrugBank ID DB01229
KEGG ID D00491
MeSH ID D017239
PubChem ID 36314
TTD Drug ID D0C4RB
NDC Product Code 0703-3213; 52222-0001; 65129-1308; 68083-179; 69539-159; 62422-0004; 68001-516; 68083-178; 0703-4768; 68554-0061; 46708-622; 47781-595; 62332-621; 62332-622; 63323-763; 72205-063; 60505-6230; 62332-620; 72205-062; 0517-4300; 0703-3216; 0703-3218; 17359-3055; 63126-902; 69539-158; 72205-061; 17359-4056; 49452-4961; 51446-0110; 59651-605; 0703-4764; 51446-0120; 46708-620; 61703-342; 68083-180; 0703-3217; 17359-4040; 62422-0002; 69539-157; 70860-215; 42533-111; 54893-0007; 65129-2039; 69443-022; 16714-137; 68817-134; 70860-200; 17359-4055; 65892-002; 24979-710; 46708-621
UNII P88XT4IS4D
Synonyms Paclitaxel | Anzatax | NSC-125973 | NSC 125973 | NSC125973 | Taxol | Taxol A | Bris Taxol | Taxol, Bris | Paclitaxel, (4 alpha)-Isomer | Paxene | Praxel | 7-epi-Taxol | 7 epi Taxol | Onxol
Chemical Information
Molecular Formula C47H51NO14
CAS Registry Number 33069-62-4
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6) O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin fibrosis23.03.03.061--Not Available
Subileus07.13.01.0040.000280%Not Available
Ejection fraction decreased13.14.02.003--
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Skin tightness23.03.03.0180.000168%Not Available
Cystitis-like symptom20.02.03.0040.000381%Not Available
Musculoskeletal chest pain22.09.01.001; 15.03.04.012--
Madarosis23.02.02.004; 06.06.04.010--Not Available
Facial paresis17.04.03.0020.000280%
Bile duct stenosis09.02.02.0010.000168%
Systemic inflammatory response syndrome24.06.03.008; 10.02.01.008; 08.01.05.0050.000112%Not Available
Malignant neoplasm progression16.16.01.0050.004085%Not Available
Acute coronary syndrome02.02.02.015; 24.04.04.0110.000728%Not Available
Necrotising colitis07.08.01.013--Not Available
Metastases to peritoneum16.22.02.008; 07.21.03.0030.000224%Not Available
Ear pruritus04.03.01.0110.000112%Not Available
Eye pruritus06.04.05.006--Not Available
Circumoral oedema23.04.01.012; 10.01.05.0130.000224%Not Available
Catheter site erythema23.03.06.014; 12.07.02.003; 08.02.02.0030.000112%Not Available
Lymphatic disorder01.09.01.0030.000168%Not Available
Electrocardiogram repolarisation abnormality13.14.05.011--Not Available
Deafness bilateral04.02.01.0070.000112%Not Available
Adenocarcinoma pancreas16.13.10.002; 07.21.09.0030.000224%Not Available
Cardiac flutter02.03.02.0120.000168%Not Available
Nerve injury17.02.10.007; 12.01.12.002--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Febrile bone marrow aplasia08.05.02.005; 01.03.03.0070.000112%Not Available
Clonic convulsion17.12.03.0080.000168%Not Available
Injection site swelling12.07.03.018; 08.02.03.017--Not Available
Infusion site pain12.07.05.002; 08.02.05.0140.000280%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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