Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Paclitaxel
Drug ID BADD_D01653
Description Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Indications and Usage Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer.
Marketing Status approved; vet_approved
ATC Code L01CD01
DrugBank ID DB01229
KEGG ID D00491
MeSH ID D017239
PubChem ID 36314
TTD Drug ID D0C4RB
NDC Product Code 0703-3213; 52222-0001; 65129-1308; 68083-179; 69539-159; 62422-0004; 68001-516; 68083-178; 0703-4768; 68554-0061; 46708-622; 47781-595; 62332-621; 62332-622; 63323-763; 72205-063; 60505-6230; 62332-620; 72205-062; 0517-4300; 0703-3216; 0703-3218; 17359-3055; 63126-902; 69539-158; 72205-061; 17359-4056; 49452-4961; 51446-0110; 59651-605; 0703-4764; 51446-0120; 46708-620; 61703-342; 68083-180; 0703-3217; 17359-4040; 62422-0002; 69539-157; 70860-215; 42533-111; 54893-0007; 65129-2039; 69443-022; 16714-137; 68817-134; 70860-200; 17359-4055; 65892-002; 24979-710; 46708-621
UNII P88XT4IS4D
Synonyms Paclitaxel | Anzatax | NSC-125973 | NSC 125973 | NSC125973 | Taxol | Taxol A | Bris Taxol | Taxol, Bris | Paclitaxel, (4 alpha)-Isomer | Paxene | Praxel | 7-epi-Taxol | 7 epi Taxol | Onxol
Chemical Information
Molecular Formula C47H51NO14
CAS Registry Number 33069-62-4
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6) O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.003750%Not Available
Intestinal ischaemia24.04.08.001; 07.15.02.0010.000280%Not Available
Intestinal obstruction07.13.01.0020.000560%Not Available
Intestinal perforation07.04.06.0020.000616%Not Available
Jaundice09.01.01.004; 01.06.04.004; 23.03.03.0300.000839%Not Available
Jaundice cholestatic09.01.01.0050.000168%Not Available
Jaundice neonatal18.04.08.001; 09.01.01.008; 01.06.04.0060.000168%Not Available
Joint swelling15.01.02.004--Not Available
Keratitis06.04.02.0020.000168%
Kidney transplant rejection12.02.10.004; 10.02.03.003; 20.01.02.0090.000112%Not Available
Lacrimation increased06.08.02.004--
Large intestine perforation12.02.03.005; 07.04.06.0050.000448%
Laryngeal oedema22.04.02.001; 10.01.05.003; 23.04.01.0050.000560%
Laryngeal pain22.12.03.0100.000224%
Laryngospasm22.04.02.0020.001287%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.002--
Leukoencephalopathy17.13.02.0030.000168%
Leukopenia01.02.02.0010.006481%Not Available
Liver disorder09.01.08.0010.001366%Not Available
Liver function test abnormal13.03.04.030--Not Available
Lividity23.06.05.0090.000168%Not Available
Loss of consciousness17.02.04.0040.006178%Not Available
Lung consolidation22.01.02.0100.000112%Not Available
Lung disorder22.02.07.0010.001287%Not Available
Lung infiltration22.01.02.0040.000224%Not Available
Lymphadenopathy01.09.01.002--Not Available
Lymphoedema01.09.01.006; 24.09.01.0010.000783%
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ADReCS-Target
Drug Name ADR Term Target
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