Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Oxtriphylline
Drug ID BADD_D01642
Description Oxtriphylline is the choline salt form of [theophylline]. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued. In the US, oxtriphylline is no longer available.
Indications and Usage Used to treat the symptoms of asthma, bronchitis, COPD, and emphysema.
Marketing Status Prescription; Discontinued
ATC Code R03DA02
DrugBank ID DB01303
KEGG ID D02017
MeSH ID C012839
PubChem ID 656652
TTD Drug ID D0B0SH
NDC Product Code Not Available
Synonyms cholinophyllin | oxtriphylline | choline theophyllinate | cholinetheophyllinate | Brondecon | Theobret | Choledyl-SA | Euspirax | oxtripylline-SA | Brondaxin | Choledyl
Chemical Information
Molecular Formula C12H21N5O3
CAS Registry Number 4499-40-5
SMILES CN1C(=C2C(=NC=N2)N(C1=O)C)[O-].C[N+](C)(C)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Agitation19.06.02.001; 17.02.05.012--
Albuminuria20.02.01.001--Not Available
Alopecia23.02.02.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Extrasystoles02.03.02.003--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haemorrhagic disorder24.07.01.021; 01.01.03.004--Not Available
Headache17.14.01.001--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypotension24.06.03.002--
Insomnia17.15.03.002; 19.02.01.002--
Irritability19.04.02.013; 08.01.03.011--
Leukopenia01.02.02.001--Not Available
Muscle twitching15.05.03.005--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Peptic ulcer07.04.07.001--Not Available
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.010--
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