Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Oxazepam
Drug ID BADD_D01636
Description Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feature is advantageous as compared to other benzodiazepines, and is likely owing in part to oxazepam's relatively simple metabolism.[A203516] It is an active metabolite of both [diazepam] and [temazepam][A39486] and undergoes very little biotransformation following absorption, making it unlikely to participate in pharmacokinetic interactions.[L13895]
Indications and Usage Oxazepam is indicated for the management of anxiety disorders and for the short-term relief of symptoms of anxiety.[L13895] It may also be used in the management of alcohol withdrawal symptoms.[L13895]
Marketing Status approved
ATC Code N05BA04
DrugBank ID DB00842
KEGG ID D00464
MeSH ID D010076
PubChem ID 4616
TTD Drug ID D09LDR
NDC Product Code 64330-015; 12828-0024; 43353-965; 52817-292; 71610-639; 62584-814; 48087-0087; 72166-009; 43353-980; 52817-291; 62584-813; 0228-2073; 62584-812; 0228-2069; 0228-2067; 52817-290
UNII 6GOW6DWN2A
Synonyms Oxazepam | Serax | Tazepam | Adumbran
Chemical Information
Molecular Formula C15H11ClN2O2
CAS Registry Number 604-75-1
SMILES C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Suicide attempt19.12.01.0040.015958%
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.0070.003800%Not Available
Tension19.06.02.0050.003040%Not Available
Tremor17.01.06.0020.006839%
Urticaria23.04.02.001; 10.01.06.001--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Mobility decreased15.03.05.023; 17.02.05.018; 08.01.03.0300.001520%Not Available
Paradoxical drug reaction08.06.01.014--Not Available
Psychomotor skills impaired19.22.01.002; 17.02.10.0050.001520%Not Available
General physical health deterioration08.01.03.0180.004103%Not Available
Balance disorder08.01.03.081; 17.02.02.007--Not Available
Deep vein thrombosis24.01.02.0030.001520%Not Available
Musculoskeletal stiffness15.03.05.0270.001520%Not Available
Bronchopneumopathy22.02.07.0100.002280%Not Available
Foetal death18.01.02.003; 08.04.01.0110.001520%
Cognitive disorder19.21.02.001; 17.03.03.0030.003040%
Freezing phenomenon17.01.05.0060.002280%Not Available
Appetite disorder19.09.01.002; 14.03.01.0040.001520%Not Available
Libido disorder21.03.02.006; 19.08.03.004--Not Available
Mental disorder19.07.01.0020.001520%Not Available
Motor dysfunction17.01.02.031; 15.05.06.006--Not Available
Abnormal behaviour19.01.01.0010.001520%Not Available
Parkinson's disease17.01.05.0100.001520%Not Available
Blood disorder01.05.01.004--Not Available
Psychotic disorder19.03.01.0020.001520%
Unevaluable event08.01.03.0510.001520%Not Available
Poor quality sleep19.02.05.005; 17.15.04.0020.002280%Not Available
Psychiatric decompensation19.01.02.0100.001520%Not Available
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