Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Optimark
Drug ID BADD_D01621
Description Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.
Indications and Usage Gadoversetamide is an MRI contrast agent used for MRI diagnostic procedures to provide increased enhancement and visualization of lesions of the brain, spine and liver, including tumors.
Marketing Status Prescription
ATC Code V08CA06
DrugBank ID DB00538
KEGG ID D01646
MeSH ID C112666
PubChem ID 6435809
TTD Drug ID D0X0GI
NDC Product Code Not Available
Synonyms gadoversetamide | OptiMARK
Chemical Information
Molecular Formula C20H34GdN5O10
CAS Registry Number 131069-91-5
SMILES COCCNC(=O)CN(CCN(CCN(CC(=O)NCCOC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Oliguria20.01.03.004--Not Available
Pain08.01.08.004--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Parosmia17.04.04.002; 22.04.03.007--Not Available
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.012--
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.017--
Peripheral coldness08.01.09.010; 24.04.03.006--Not Available
Peripheral vascular disorder24.03.01.003--Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.016--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Proctalgia07.03.02.001--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash macular23.03.13.003--Not Available
Rhinitis11.01.13.004; 22.07.03.006--
Rhinorrhoea22.02.05.010--
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.001--
Sensory loss17.02.07.007--Not Available
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
Sleep disorder19.02.04.001--Not Available
Sneezing22.02.05.011--
Somnolence19.02.05.003; 17.02.04.006--
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