Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ofloxacin
Drug ID BADD_D01598
Description A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Indications and Usage For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
Marketing Status Prescription; Discontinued
ATC Code J01MA01; S01AE01; S02AA16
DrugBank ID DB01165
KEGG ID D00453
MeSH ID D015242
PubChem ID 4583
TTD Drug ID D03NHW
NDC Product Code 59390-140; 68047-713; 68071-2544; 71205-420; 63187-472; 55111-161; 71209-097; 75834-119; 68071-1588; 68788-7693; 24208-434; 63187-268; 71209-098; 11980-779; 70518-1892; 68071-2254; 68071-1607; 50383-024; 64980-515; 71209-099; 50090-5425; 50090-1090; 58032-0090; 63187-184; 63187-734; 13985-602; 55111-160; 68071-1630; 68071-5150; 63187-662; 68071-2265; 68071-4832; 50090-5186; 53002-1324; 75834-120; 55111-162; 53002-1604; 59116-1820; 50090-5209; 50090-0891; 60505-0363; 53002-2604; 60505-0560; 50090-1346; 50090-5210; 72969-108; 24208-410; 63629-8716; 0404-7189; 61919-931; 75834-112; 17478-713; 72189-108; 53069-0440
Synonyms Ofloxacin | Ofloxacine | Tarivid | ORF-28489 | ORF 28489 | ORF28489 | DR-3355 | DR 3355 | DR3355 | Hoe-280 | Hoe 280 | Hoe280 | Ofloxacin Hydrochloride | Ru-43280 | Ru 43280 | Ru43280 | DL-8280 | DL 8280 | DL8280
Chemical Information
Molecular Formula C18H20FN3O4
CAS Registry Number 82419-36-1
SMILES CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Acidosis14.01.03.002--
Acute hepatic failure09.01.03.0010.000104%Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Albuminuria20.02.01.001--Not Available
Alveolitis allergic22.01.01.002; 10.01.03.008--Not Available
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000597%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.0090.000796%Not Available
Anuria20.01.03.002--Not Available
Anxiety19.06.02.0020.000796%
Aphasia19.21.01.001; 17.02.03.0010.000398%
Application site pruritus23.03.12.004; 12.07.01.005; 08.02.01.005--Not Available
Application site reaction08.02.01.006; 12.07.01.006--Not Available
Arthralgia15.01.02.0010.000597%
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Atrial fibrillation02.03.03.0020.000104%
Blister23.03.01.001; 12.01.06.0020.000597%Not Available
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Breath odour07.01.06.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.0010.000156%
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