Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Norfloxacin
Drug ID BADD_D01587
Description A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Indications and Usage For the treatment of urinary tract infection
Marketing Status Discontinued
ATC Code J01MA06; S01AE02
DrugBank ID DB01059
KEGG ID D00210
MeSH ID D009643
PubChem ID 4539
TTD Drug ID D0Q2PE
NDC Product Code 53104-7517
Synonyms Norfloxacin | MK-0366 | MK 0366 | MK-366 | MK 366 | MK0366 | MK366 | Noroxin | AM-0715 | AM 0715 | AM0715 | AM-715 | AM 715
Chemical Information
Molecular Formula C16H18FN3O3
CAS Registry Number 70458-96-7
SMILES CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
White blood cell count decreased13.01.06.012--
Tubulointerstitial nephritis20.05.02.002--Not Available
Hypoacusis04.02.01.006--
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
Candiduria20.02.01.016; 11.03.03.009--Not Available
Acute coronary syndrome02.02.02.015; 24.04.04.011--Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Anxiety disorder19.06.01.002--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Psychotic disorder19.03.01.002--
Vulvovaginal mycotic infection21.14.02.004; 11.03.05.004--Not Available
Anal pruritus07.03.03.002--Not Available
Anorectal discomfort07.03.03.003--Not Available
Vulvovaginal swelling21.08.02.016--Not Available
Liver function test increased13.03.01.044--Not Available
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