Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitroglycerin
Drug ID BADD_D01579
Description Nitroglycerin is a vasodilator drug used for the treatment of chest pain and high blood pressure.[T628,L4429] It was first approved in 2000 and is currently marketed by Pfizer, and other companies, depending on the dosage form.[T628,L4894] Nitroglycerin is available in various forms, including a spray form, sublingual tablet form, intravenous form, extended-release tablet form, and transdermal form. A less commonly known fact is that in addition to treating angina, nitroglycerin is also used in an ointment to treat the pain that accompanies anal fissures. The rectal ointment form of nitroglycerin was approved by the FDA in 1955.[L7096]
Indications and Usage For the prevention of angina
Marketing Status Prescription; Discontinued
ATC Code C01DA02; C05AE01
DrugBank ID DB00727
KEGG ID D00515
MeSH ID D005996
PubChem ID 4510
TTD Drug ID D07YDE
NDC Product Code 59762-4921; 51662-1340; 68071-2260; 28595-550; 60429-839; 0338-1051; 0378-9116; 52584-810; 47781-456; 0904-5495; 50090-4874; 0338-1047; 0220-2291; 43598-895; 0220-2287; 0281-0326; 63629-8829; 71872-7010; 51662-1282; 71872-7201; 70518-0545; 49483-223; 64117-543; 43598-896; 50742-516; 71205-225; 0378-9104; 0220-2283; 0071-0418; 76299-430; 63629-8830; 50742-517; 59762-0489; 49483-222; 0220-2279; 60429-840; 71872-7033; 0404-9928; 0378-9102; 50090-3266; 68428-407; 71205-482; 0220-2290; 50742-514; 0404-9929; 43598-435; 47781-457; 52584-418; 0517-4810; 0904-0643; 45802-210; 68071-4909; 42291-648; 28595-705; 0220-2286; 70518-0105; 50742-515; 50742-518; 0378-9112; 50742-513; 0338-1049; 43598-893; 70518-2910; 0220-2282; 0904-0647; 51662-1386; 68462-638; 28595-120; 68071-1330; 50090-0332; 50090-0133; 59762-3304; 51662-1351; 63187-884; 51662-1244; 68428-100; 68071-1720; 60429-841; 63629-8828; 0220-2293; 0071-0417; 0904-5497; 43598-437; 0904-5496; 43598-894; 68428-050; 47781-458; 0071-0419; 68462-639; 43598-436; 58914-301; 49483-221; 68462-640
Synonyms Nitroglycerin | Glyceryl Trinitrate | Trinitrate, Glyceryl | Nitrolan | Nitrospan | Nitrostat | Perlinganit | Nitrong | Susadrin | Sustac | Sustak | Sustonit | Transderm Nitro | Nitroglyn | Trinitrin | Trinitrolong | Anginine | Dynamite | Gilustenon | Nitrangin | Nitro-Bid | Nitro Bid | NitroBid | Nitro-Dur | Nitro Dur | NitroDur | Nitrocard | Nitroderm | Nitroderm TTS | Nitrol | Tridil
Chemical Information
Molecular Formula C3H5N3O9
CAS Registry Number 55-63-0
SMILES C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infection11.01.08.002--Not Available
Intracranial pressure increased17.07.02.002--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.000423%
Loss of consciousness17.02.04.0040.001833%Not Available
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
Methaemoglobinaemia01.05.01.0020.001269%
Migraine24.03.05.003; 17.14.02.0010.000705%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.0010.000564%
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000147%Not Available
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nodal rhythm02.03.02.0060.000282%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.000705%
Oral discomfort07.05.05.0010.000423%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.0200.000282%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pallor08.01.03.032; 24.03.04.001; 23.03.03.0310.000987%Not Available
Palpitations02.01.02.0030.000987%
Paraesthesia17.02.06.0050.001269%
Paralysis17.01.04.004--Not Available
Petechiae01.01.03.002; 24.07.06.004; 23.06.01.0030.000282%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photopsia17.17.01.006; 06.02.06.0040.000282%
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.0070.000987%
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