Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitroglycerin
Drug ID BADD_D01579
Description Nitroglycerin is a vasodilator drug used for the treatment of chest pain and high blood pressure.[T628,L4429] It was first approved in 2000 and is currently marketed by Pfizer, and other companies, depending on the dosage form.[T628,L4894] Nitroglycerin is available in various forms, including a spray form, sublingual tablet form, intravenous form, extended-release tablet form, and transdermal form. A less commonly known fact is that in addition to treating angina, nitroglycerin is also used in an ointment to treat the pain that accompanies anal fissures. The rectal ointment form of nitroglycerin was approved by the FDA in 1955.[L7096]
Indications and Usage For the prevention of angina
Marketing Status Prescription; Discontinued
ATC Code C01DA02; C05AE01
DrugBank ID DB00727
KEGG ID D00515
MeSH ID D005996
PubChem ID 4510
TTD Drug ID D07YDE
NDC Product Code 59762-4921; 51662-1340; 68071-2260; 28595-550; 60429-839; 0338-1051; 0378-9116; 52584-810; 47781-456; 0904-5495; 50090-4874; 0338-1047; 0220-2291; 43598-895; 0220-2287; 0281-0326; 63629-8829; 71872-7010; 51662-1282; 71872-7201; 70518-0545; 49483-223; 64117-543; 43598-896; 50742-516; 71205-225; 0378-9104; 0220-2283; 0071-0418; 76299-430; 63629-8830; 50742-517; 59762-0489; 49483-222; 0220-2279; 60429-840; 71872-7033; 0404-9928; 0378-9102; 50090-3266; 68428-407; 71205-482; 0220-2290; 50742-514; 0404-9929; 43598-435; 47781-457; 52584-418; 0517-4810; 0904-0643; 45802-210; 68071-4909; 42291-648; 28595-705; 0220-2286; 70518-0105; 50742-515; 50742-518; 0378-9112; 50742-513; 0338-1049; 43598-893; 70518-2910; 0220-2282; 0904-0647; 51662-1386; 68462-638; 28595-120; 68071-1330; 50090-0332; 50090-0133; 59762-3304; 51662-1351; 63187-884; 51662-1244; 68428-100; 68071-1720; 60429-841; 63629-8828; 0220-2293; 0071-0417; 0904-5497; 43598-437; 0904-5496; 43598-894; 68428-050; 47781-458; 0071-0419; 68462-639; 43598-436; 58914-301; 49483-221; 68462-640
Synonyms Nitroglycerin | Glyceryl Trinitrate | Trinitrate, Glyceryl | Nitrolan | Nitrospan | Nitrostat | Perlinganit | Nitrong | Susadrin | Sustac | Sustak | Sustonit | Transderm Nitro | Nitroglyn | Trinitrin | Trinitrolong | Anginine | Dynamite | Gilustenon | Nitrangin | Nitro-Bid | Nitro Bid | NitroBid | Nitro-Dur | Nitro Dur | NitroDur | Nitrocard | Nitroderm | Nitroderm TTS | Nitrol | Tridil
Chemical Information
Molecular Formula C3H5N3O9
CAS Registry Number 55-63-0
SMILES C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.000846%
Acute myocardial infarction02.02.02.001; 24.04.04.0010.000564%Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.0010.000705%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000423%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.000564%
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Angle closure glaucoma06.03.01.0010.000282%Not Available
Aortic aneurysm24.02.03.0010.000282%Not Available
Application site erythema12.07.01.001; 08.02.01.001; 23.03.06.005--Not Available
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Application site pruritus23.03.12.004; 12.07.01.005; 08.02.01.005--Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Arrhythmia02.03.02.0010.000423%Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.0050.000282%Not Available
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.0030.000705%
Back pain15.03.04.005--
Blood creatine phosphokinase increased13.04.01.0010.000282%
Blood pressure decreased13.14.03.0020.002115%Not Available
Blood pressure increased13.14.03.0050.000846%Not Available
Blood pressure systolic decreased13.14.03.0070.000282%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.003243%Not Available
Breath odour07.01.06.002--Not Available
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